| pubmed-article:8367463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C0022245 | lld:lifeskim |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C0443213 | lld:lifeskim |
| pubmed-article:8367463 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:8367463 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:8367463 | pubmed:dateCreated | 1993-10-5 | lld:pubmed |
| pubmed-article:8367463 | pubmed:abstractText | beta-Agonists cause an inhibition of contractility and a transient stimulation of Na+/K+ pumping in smooth muscle cells of the stomach from the toad Bufo marinus. To determine if the stimulation of Na+/K+ pumping causes changes in intracellular [Na+] ([Na+]i) that might link Na+ pump stimulation to decrease Ca2+ availability for contraction, [Na+]i was measured in these cells with SBFI, a Na(+)-sensitive fluorescent indicator. Basal [Na+]i was 12.8 +/- 4.2 mM (n = 32) and was uniform throughout the cell. In response to isoproterenol, [Na+]i decreased an average of 7.1 +/- 1.1 mM in 3 sec. Since this decrease in [Na+]i could be completely blocked by inhibition of the Na+ pump, or by blockade of the beta-receptor, [Na+]i reduction is the result of occupation of the beta-receptor by isoproterenol and subsequent stimulation of the Na+ pump. 8-Bromoadenosine 3',5'-cyclic monophosphate and forskolin mimicked the effect of isoproterenol, indicating that the sequence of events linking beta-receptor occupation to Na+ pump stimulation most likely includes activation of adenylate cyclase, production of cAMP, and stimulation of cAMP-dependent protein kinase. The decrease in [Na+]i is sufficiently large and fast that it is expected to stimulate turnover of the Na+/Ca2+ exchanger in the Ca2+ extrusion mode, thereby accounting for the observed linkage between stimulation of the Na+/K+ pump and inhibition of contractility in response to beta-adrenergic agonists. | lld:pubmed |
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| pubmed-article:8367463 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8367463 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8367463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8367463 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8367463 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8367463 | pubmed:author | pubmed-author:KRAS JSJ | lld:pubmed |
| pubmed-article:8367463 | pubmed:author | pubmed-author:MooreE DED | lld:pubmed |
| pubmed-article:8367463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8367463 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8367463 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8367463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8367463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8367463 | pubmed:pagination | 8058-62 | lld:pubmed |
| pubmed-article:8367463 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8367463 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8367463 | pubmed:articleTitle | Isoproterenol stimulates rapid extrusion of sodium from isolated smooth muscle cells. | lld:pubmed |
| pubmed-article:8367463 | pubmed:affiliation | Department of Physiology, University of Massachusetts Medical Center, Worcester 01605. | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8367463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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