| pubmed-article:8346443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0332162 | lld:lifeskim |
| pubmed-article:8346443 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:8346443 | pubmed:issue | 5123 | lld:pubmed |
| pubmed-article:8346443 | pubmed:dateCreated | 1993-9-8 | lld:pubmed |
| pubmed-article:8346443 | pubmed:abstractText | The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80. | lld:pubmed |
| pubmed-article:8346443 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8346443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8346443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8346443 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8346443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8346443 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8346443 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:RosesA DAD | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:StrittmatterW... | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:SaundersA MAM | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:SchmechelD... | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:Pericak-Vance... | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:CorderE HEH | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:HainesJ LJL | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:SmallG WGW | lld:pubmed |
| pubmed-article:8346443 | pubmed:author | pubmed-author:GaskellP CPC | lld:pubmed |
| pubmed-article:8346443 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8346443 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:8346443 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:8346443 | pubmed:geneSymbol | APOE-&egr;4 | lld:pubmed |
| pubmed-article:8346443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8346443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8346443 | pubmed:pagination | 921-3 | lld:pubmed |
| pubmed-article:8346443 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8346443 | pubmed:meshHeading | pubmed-meshheading:8346443-... | lld:pubmed |
| pubmed-article:8346443 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8346443 | pubmed:articleTitle | Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. | lld:pubmed |
| pubmed-article:8346443 | pubmed:affiliation | Department of Medicine, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710. | lld:pubmed |
| pubmed-article:8346443 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8346443 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8346443 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:348 | entrezgene:pubmed | pubmed-article:8346443 | lld:entrezgene |
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