| pubmed-article:8344353 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0036319 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:8344353 | lifeskim:mentions | umls-concept:C0439098 | lld:lifeskim |
| pubmed-article:8344353 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8344353 | pubmed:dateCreated | 1993-9-3 | lld:pubmed |
| pubmed-article:8344353 | pubmed:abstractText | When cultured in vitro with either mitogen or parasite antigens, spleen cells from mice infected with Schistosoma mansoni produce significantly higher levels of IL-4 than splenocytes from control animals. Previous studies suggested that this increase in IL-4 production occurs because of a selective expansion of T helper type 2 (Th2) cells in infected mice. However, these experiments employed unfractionated spleen populations rather than purified T lymphocytes. Here we demonstrate that T-depleted spleen cells from infected animals synthesize high levels of interleukin-4 (IL-4), but no IL-5 when stimulated with parasite antigen in vitro. Nevertheless, when purified by sorting, T cells and non-B, non-T (NBNT) populations produced similar amounts of IL-4 in response to parasite antigen. The IL-4 producing NBNT cells were found to belong to an Fc epsilon receptor (Fc epsilon R)-positive population which after sort purification produced high levels of IL-4 (between 1000 and 2000 U of per 5 x 10(3) cells). FACS analysis revealed that these Fc epsilon R+ cells make up 0.53% of splenic NBNT cells in control animals while in 8-9-week-infected animals they increase to 3.8% of that population. In contrast, in mice with 8-week unisexual worm infections these cells comprise only 1.71% of NBNT cells, indicating that eggs are a major stimulus of the response. The expansion of Fc epsilon R+ cells and their production of IL-4 could be an important factor regulating the selection and induction of different CD4+ subsets in schistosome-infected hosts. | lld:pubmed |
| pubmed-article:8344353 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8344353 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8344353 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8344353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8344353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8344353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8344353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8344353 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8344353 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8344353 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:BerzofskyJ... | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:SherAA | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:WilliamsM EME | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:BarbieriSS | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:SederR ARA | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:CasparPP | lld:pubmed |
| pubmed-article:8344353 | pubmed:author | pubmed-author:KullbergM CMC | lld:pubmed |
| pubmed-article:8344353 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8344353 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:8344353 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8344353 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8344353 | pubmed:pagination | 1910-6 | lld:pubmed |
| pubmed-article:8344353 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
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| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:meshHeading | pubmed-meshheading:8344353-... | lld:pubmed |
| pubmed-article:8344353 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8344353 | pubmed:articleTitle | Fc epsilon receptor-positive cells are a major source of antigen-induced interleukin-4 in spleens of mice infected with Schistosoma mansoni. | lld:pubmed |
| pubmed-article:8344353 | pubmed:affiliation | Immunology and Cell Biology Section, NCI, NIH, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:8344353 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8344353 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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