| pubmed-article:8340603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C0276623 | lld:lifeskim |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C0596570 | lld:lifeskim |
| pubmed-article:8340603 | lifeskim:mentions | umls-concept:C0162491 | lld:lifeskim |
| pubmed-article:8340603 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8340603 | pubmed:dateCreated | 1993-8-31 | lld:pubmed |
| pubmed-article:8340603 | pubmed:abstractText | Forty patients with chronic viral hepatitis or active cirrhosis (33 anti-HCV positive) entered a recombinant human alpha 2A interferon randomized trial. Twenty-one subjects were treated with 6 million units (MU) three times per week for 6 months. Nineteen were not treated. Six months later in 12 patients of the treated group (60% of the evaluable 20) with normalized serum aminotransferases levels (responders), fibrogenesis serum markers (NPIIIP and laminin) were significantly lower than baseline. In the untreated patients and in non-responders NPIIIP and laminin were unchanged. Semi quantitative histological evaluation (allotting scores for inflammation, necrosis and fibrosis) confirmed a significant improvement of necro-inflammation in the responders. These data suggest that alpha-IFN treatment may decrease stimuli for fibrogenesis by reducing liver inflammation and necrosis, thus preventing evolution to cirrhosis. | lld:pubmed |
| pubmed-article:8340603 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8340603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8340603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8340603 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8340603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8340603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8340603 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8340603 | pubmed:issn | 0168-8278 | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:De SandreGG | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:CorrocherRR | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:CasarilMM | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:GabrielliG... | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:ColombariRR | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:RizziAA | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:CapraFF | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:MezzelaniPP | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:DolciLL | lld:pubmed |
| pubmed-article:8340603 | pubmed:author | pubmed-author:TognellaPP | lld:pubmed |
| pubmed-article:8340603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8340603 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:8340603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8340603 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8340603 | pubmed:pagination | 112-8 | lld:pubmed |
| pubmed-article:8340603 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8340603 | pubmed:meshHeading | pubmed-meshheading:8340603-... | lld:pubmed |
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| pubmed-article:8340603 | pubmed:meshHeading | pubmed-meshheading:8340603-... | lld:pubmed |
| pubmed-article:8340603 | pubmed:meshHeading | pubmed-meshheading:8340603-... | lld:pubmed |
| pubmed-article:8340603 | pubmed:meshHeading | pubmed-meshheading:8340603-... | lld:pubmed |
| pubmed-article:8340603 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8340603 | pubmed:articleTitle | alpha-Interferon in the treatment of chronic viral hepatitis: effects on fibrogenesis serum markers. | lld:pubmed |
| pubmed-article:8340603 | pubmed:affiliation | Istituto di Clinica Medica, dell'Università di Verona, Italy. | lld:pubmed |
| pubmed-article:8340603 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8340603 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8340603 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8340603 | lld:pubmed |
