| pubmed-article:8335941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8335941 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8335941 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:8335941 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:8335941 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8335941 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8335941 | pubmed:dateCreated | 1993-8-26 | lld:pubmed |
| pubmed-article:8335941 | pubmed:abstractText | Microglia have been proposed to play a pathogenetic role in immunologically mediated neurodegenerative diseases. In our study, using microglial/neuronal cell cocultures primed with IFN-gamma, we found that both LPS and TNF-alpha triggered neuronal cell injury (impairment of gamma-aminobutyric acid uptake and neuronal loss) via a nitric oxide mechanism. Pretreatment of cell cocultures with IL-4, an immunosuppressive cytokine, prevented, in a dose-dependent manner, neuronal cell injury induced by activated microglia. The mechanism by which IL-4 exerts its neuroprotective effect was found to involve the inhibition of IFN-gamma priming of microglia with a subsequent decrease in the production of TNF-alpha and nitric oxide. | lld:pubmed |
| pubmed-article:8335941 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8335941 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8335941 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8335941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8335941 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8335941 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8335941 | pubmed:author | pubmed-author:MolitorT WTW | lld:pubmed |
| pubmed-article:8335941 | pubmed:author | pubmed-author:HoYY | lld:pubmed |
| pubmed-article:8335941 | pubmed:author | pubmed-author:ChaoC CCC | lld:pubmed |
| pubmed-article:8335941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8335941 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8335941 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:8335941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8335941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8335941 | pubmed:pagination | 1473-81 | lld:pubmed |
| pubmed-article:8335941 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8335941 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8335941 | pubmed:articleTitle | Neuroprotective role of IL-4 against activated microglia. | lld:pubmed |
| pubmed-article:8335941 | pubmed:affiliation | Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404. | lld:pubmed |
| pubmed-article:8335941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8335941 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8335941 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8335941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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