| pubmed-article:8334993 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0167954 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8334993 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8334993 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8334993 | pubmed:dateCreated | 1993-8-20 | lld:pubmed |
| pubmed-article:8334993 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334993 | pubmed:abstractText | The transient expression of many different genes is mediated by the inducible transcription factor p50-p65 NF kappa B, which in turn is regulated by complex formation with its inhibitor I kappa B alpha. We describe here that in porcine aortic endothelial cells, either IL-1 alpha, TNF alpha or LPS upregulates an inhibitor of NF kappa B which we refer to as ECI-6. ECI-6 is by structural and functional criteria an I kappa B alpha protein, the porcine homologue of MAD-3, pp40 and RL/IF-1. We have studied the promoter of the ECI-6/I kappa B alpha gene and provide three lines of evidence that its expression is directly regulated by NF kappa B. First, the 5' regulatory region of ECI-6/I kappa B alpha contains two sites that bind NF kappa B in electrophoretic mobility shift assays. Second, expression following transfection of an ECI-6/I kappa B alpha promoter-luciferase reporter construct is dependent on a co-transfected NF kappa B-p65 subunit. Third, pretreatment of endothelial cells with antioxidants, agents that inhibit activation of NF kappa B, inhibit the expression of ECI-6/I kappa B alpha. We conclude that the regulated expression of ECI-6/I kappa B alpha could represent a novel feedback mechanism by which NF kappa B downregulates its own activity after transient activation of target genes has been achieved. | lld:pubmed |
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| pubmed-article:8334993 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8334993 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334993 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8334993 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334993 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8334993 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8334993 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8334993 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:BachF HFH | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:HoferEE | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:WinklerHH | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:ChengQQ | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:VanhoveBB | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:de MartinRR | lld:pubmed |
| pubmed-article:8334993 | pubmed:author | pubmed-author:CsizmadiaVV | lld:pubmed |
| pubmed-article:8334993 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8334993 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8334993 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8334993 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8334993 | pubmed:pagination | 2773-9 | lld:pubmed |
| pubmed-article:8334993 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8334993 | pubmed:meshHeading | pubmed-meshheading:8334993-... | lld:pubmed |
| pubmed-article:8334993 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8334993 | pubmed:articleTitle | Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. | lld:pubmed |
