| pubmed-article:8332448 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C0021798 | lld:lifeskim |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C0432408 | lld:lifeskim |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C0162788 | lld:lifeskim |
| pubmed-article:8332448 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8332448 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8332448 | pubmed:dateCreated | 1993-8-13 | lld:pubmed |
| pubmed-article:8332448 | pubmed:abstractText | Trisomy 12 is the most common cytogenetic abnormality in chronic lymphocytic leukaemia (CLL) and may be a prognostic indicator. In the present study, fluorescence in situ hybridization (FISH) is shown to be a method of choice for detection of trisomy 12 in interphase cells. Seventy-five cases of B-cell CLL were analysed with a chromosome 12 specific alpha satellite DNA probe and results compared with those from cytogenetic analysis. FISH showed the three hybridization spots characteristic of trisomy 12 in 32/75 patients (42.6%). Sixty-three patients were also studied by conventional cytogenetics: failure in 7 cases, normal karyotype in 28, trisomy 12 in 9 (14.3%) and in 19 cases abnormalities other than trisomy 12. In these same 63 patients, trisomy 12 was detected on 29 occasions by FISH (46%): in one case of failure by cytogenetic analysis, in 9 cases thought to have a normal karyotype, in 10 cases carrying abnormalities other than trisomy 12 and in all 9 cases showing trisomy 12 by conventional cytogenetic investigation. Correlation between trisomy 12 and the three stages of the Binet classification indicated an increasing proportion of trisomy 12 from stage A to stage C. It is concluded that fluorescence in situ hybridization is a powerful and sensitive technique for detection of trisomy 12 in CLL and although more cases will be required to confirm a correlation between the incidence of trisomy 12 and the stage of the disease, this link could be important from a prognostic point of view. | lld:pubmed |
| pubmed-article:8332448 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8332448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8332448 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8332448 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8332448 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:BrizardC PCP | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:ReynaudJJ | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:JaubertJJ | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:GuyotatDD | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:Calmard-Oriol... | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:VasselonCC | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:BerthéasM FMF | lld:pubmed |
| pubmed-article:8332448 | pubmed:author | pubmed-author:CoignetLL | lld:pubmed |
| pubmed-article:8332448 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:8332448 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8332448 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8332448 | pubmed:pagination | 129-34 | lld:pubmed |
| pubmed-article:8332448 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8332448 | pubmed:meshHeading | pubmed-meshheading:8332448-... | lld:pubmed |
| pubmed-article:8332448 | pubmed:meshHeading | pubmed-meshheading:8332448-... | lld:pubmed |
| pubmed-article:8332448 | pubmed:meshHeading | pubmed-meshheading:8332448-... | lld:pubmed |
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| pubmed-article:8332448 | pubmed:meshHeading | pubmed-meshheading:8332448-... | lld:pubmed |
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| pubmed-article:8332448 | pubmed:meshHeading | pubmed-meshheading:8332448-... | lld:pubmed |
| pubmed-article:8332448 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8332448 | pubmed:articleTitle | Trisomy 12 in B-cell chronic lymphocytic leukemia: interphase study by in situ hybridization in 75 patients. | lld:pubmed |
| pubmed-article:8332448 | pubmed:affiliation | Département d'Hématologie, Hôpital Nord, Saint-Priest-en-Jarez, France. | lld:pubmed |
| pubmed-article:8332448 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8332448 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
