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pubmed-article:8326250pubmed:abstractTextThe objectives of these studies were to determine if the concentration of insulin-like growth factor-I (IGF-I) in mammary colostrum secretions could be altered through manipulation of IGF-I concentrations in blood and to compare the temporal changes of IGF-I in mammary secretions to those occurring for IgG1. Milking of 15 pregnant Holstein cows was stopped at 8 weeks prepartum and they were randomly assigned to one of three treatments. A control (C) treatment consisted of feeding the animals 100% of NRC requirements for protein and energy. A second group of cows was fed as the control group and injected with 1.8 mumol bovine GH/day. The third group was fed at 70% of NRC requirements for protein and energy to cause a moderate nutrient restriction (NR). Body weight was measured weekly. Blood was collected by tail venepuncture at 4 h intervals for 24 h. Mammary secretions were collected and pooled among contralateral front and rear quarters (diagonal) for measurement of volume, IGF-I and IgG1 concentrations. Samples were collected at -7, -5, -2, 0 and 1 week postpartum. Cows on the NR treatment failed to gain weight during the dry period compared with C cows (P < 0.05). Blood GH and IGF-I concentrations (P > 0.1) were unaffected by NR treatment. Cows treated with GH had higher (P < 0.01) serum GH and IGF-I levels throughout the entire treatment period, and higher serum IgG1 at 5 and 2 weeks prepartum (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)lld:pubmed
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pubmed-article:8326250pubmed:authorpubmed-author:KensingerR...lld:pubmed
pubmed-article:8326250pubmed:authorpubmed-author:HadsellD LDLlld:pubmed
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pubmed-article:8326250pubmed:volume137lld:pubmed
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pubmed-article:8326250pubmed:pagination223-30lld:pubmed
pubmed-article:8326250pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:8326250pubmed:articleTitleEffects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase.lld:pubmed
pubmed-article:8326250pubmed:affiliationDepartment of Dairy and Animal Science, Pennsylvania State University, University Park 16802.lld:pubmed
pubmed-article:8326250pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8326250pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8326250pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed