Linked Life Data

8321625

Source:http://linkedlifedata.com/resource/pubmed/id/8321625

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pubmed-article:8321625pubmed:abstractTextWhole-cell patch-clamp recordings of membrane currents and fura-2 measurements of free intracellular calcium concentration ([Ca2+]i) were used to study Mn2+ influx in rat peritoneal mast cells. The calcium-selective current, activated by depletion of intracellular calcium stores (ICRAC for calcium release-activated calcium current), supports a small but measurable Mn2+ current. In the presence of intracellular BAPTA, a Mn2+ current through ICRAC was recorded in isotonic MnCl2 (100 mM) without a significant quenching of fura-2 fluorescence. Its amplitude was 10% of that measured in physiological solution containing 10 mM Ca2+. However, following store depletion, a significant quenching of fura-2 fluorescence could be measured only when intracellular BAPTA was omitted, so that all the incoming Mn2+ could be captured by the fluorescent dye. Two other ionic currents activated by receptor stimulation also induced Mn2+ quenching of fura-2 fluorescence: a small current through non-specific cation channels of 50-pS unitary conductance and a distinct cationic current of large amplitude. In addition to these influx mechanisms, Mn2+ was taken up into calcium stores and was subsequently co-released with Ca2+ by Ca(2+)-mobilizing agonists.lld:pubmed
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pubmed-article:8321625pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8321625pubmed:year1993lld:pubmed
pubmed-article:8321625pubmed:articleTitleMultiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells.lld:pubmed
pubmed-article:8321625pubmed:affiliationDepartment of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.lld:pubmed
pubmed-article:8321625pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8321625pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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