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pubmed-article:8320841rdf:typepubmed:Citationlld:pubmed
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pubmed-article:8320841pubmed:issue6lld:pubmed
pubmed-article:8320841pubmed:dateCreated1993-8-3lld:pubmed
pubmed-article:8320841pubmed:abstractTextActivation of blood fibrinolysis is initiated by the activation of plasminogen to plasmin by plasminogen activator (PA). The plasmin thus produced can degrade fibrin, the main component of thrombus. Tissue-type PA (t-PA) which is mainly secreted from vascular endothelial cells possesses a high affinity for fibrin in contrast to urokinase-type PA (u-PA). Enzymatic activity of t-PA is expressed in either single-chain form or two-chain form. Further, t-PA activity enhanced markedly in the presence of fibrin; 600-1,000-fold increase. Thus, the thrombolytic therapy is now being performed by using t-PA. The mechanism for thrombolysis by t-PA involves the activation of fibrinolytic system on the fibrin surface. The kringle 2 domain of t-PA molecule plays an important role on the binding to fibrin. But in single-chain t-PA, finger domain plays a role for its binding to fibrin. Recent studies have revealed that the t-PA specific receptor (t-PAR) is expressed on the endothelial cells which localizes t-PA activity by fixing t-PA around the cells.lld:pubmed
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pubmed-article:8320841pubmed:statusMEDLINElld:pubmed
pubmed-article:8320841pubmed:monthJunlld:pubmed
pubmed-article:8320841pubmed:issn0047-1852lld:pubmed
pubmed-article:8320841pubmed:authorpubmed-author:MatsuiEElld:pubmed
pubmed-article:8320841pubmed:authorpubmed-author:FukaiFFlld:pubmed
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pubmed-article:8320841pubmed:volume51lld:pubmed
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pubmed-article:8320841pubmed:pagination1620-6lld:pubmed
pubmed-article:8320841pubmed:dateRevised2011-7-27lld:pubmed
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pubmed-article:8320841pubmed:year1993lld:pubmed
pubmed-article:8320841pubmed:articleTitle[Molecular biology of tissue-type plasminogen activator (t-PA) and clinical application of recombinant t-PA].lld:pubmed
pubmed-article:8320841pubmed:affiliationDepartment of Physiology, Kinki University School of Medicine.lld:pubmed
pubmed-article:8320841pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8320841pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:8320841pubmed:publicationTypeReviewlld:pubmed