Linked Life Data

8320182

Source:http://linkedlifedata.com/resource/pubmed/id/8320182

Statements in which the resource exists.
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pubmed-article:8320182pubmed:abstractTextTumor cells from a spontaneously arising canine astrocytoma were isolated and cloned. Three clonally derived cell lines (DL3580 clone 1, DL3580 clone 2, and DL3580 clone 3) were developed and found to express glial fibrillary acidic protein (GFAP) as well as epidermal growth factor receptor (EGFR/c-erbB1). The cell lines were tumorigenic as subcutaneous xenografts or as intracranial implants in athymic mice, or both. Both the monolayer astrocytoma cells and the xenograft tumor cells from clone 2 were aneuploid, with a modal number of 84 chromosomes per metaphase; clones 1 and 3 were also aneuploid with modal numbers of 82 and 75/79, respectively. The histology of both the initial spontaneously occurring tumor in the dog and the intracranial astrocytoma in athymic mice demonstrated features of diffuse infiltration into normal brain. These newly developed canine glioma cell lines are karyotypically stable for 1 yr in culture and carry the same marker chromosomes as the parental lines. These glioma cell lines may serve as models for investigating mechanisms of glioma invasion into brain. Additionally, clonal cell lines with divergent properties isolated from the same tumor may assist in studies of the molecular basis of astrocytoma progression and heterogeneity.lld:pubmed
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pubmed-article:8320182pubmed:pagination310-8lld:pubmed
pubmed-article:8320182pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:8320182pubmed:year1993lld:pubmed
pubmed-article:8320182pubmed:articleTitleTumorigenic, invasive, karyotypic, and immunocytochemical characteristics of clonal cell lines derived from a spontaneous canine anaplastic astrocytoma.lld:pubmed
pubmed-article:8320182pubmed:affiliationNeuro-Oncology Laboratory, Barrow Neurological Institute of St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013.lld:pubmed
pubmed-article:8320182pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8320182pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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