| pubmed-article:8320136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C1837204 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0678257 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0062873 | lld:lifeskim |
| pubmed-article:8320136 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:8320136 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8320136 | pubmed:dateCreated | 1993-7-30 | lld:pubmed |
| pubmed-article:8320136 | pubmed:abstractText | A new HLA-DR8 allele (HLA-DRB1*0806) found in the Algerian population is described here. This allele has an exon-2 nucleotide sequence identical to that of the HLA-DRB1*0801 allele, except for a GGT to GTG change in codon 86, yielding an amino acid substitution (glycine to valine). This change is also found in other HLA-DRB1 and HLA-DRB3 evolutionary-related allele pairs. HLA-DRB1*0806 is the most frequent HLA-DR8 allele found in this population (three of eight HLA-DR8-positive individuals) and is included within the HLA-DQA1*0102-DQB1*0602 haplotype (HLA-DQ6 serotype). This combination of HLA-DQ alleles is sporadically found associated with other HLA-DR8 alleles in other ethnic groups, i.e., HLA-DRB1*0804 in Bushmen and in North American blacks and HLA-DRB1*0803 in African blacks. Also, the HLA-DRB1*0806-DQ6 haplotype only bears one HLA-DRB gene copy, a common characteristic of the HLA-DR8 haplotype family. An exon-2 HLA-DR8 dendrogram has also been constructed with the available sequence data, indicating that this new allele does not seem to be placed at a distance significantly different from the origin to that of HLA-DRB1*0804 (proposed to be the eldest in the HLA-DR8 allele diversification pathway). A possible HLA-DR8 evolutive pathway is postulated according to the available exon-2 HLA-DR8 allele sequences. | lld:pubmed |
| pubmed-article:8320136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8320136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8320136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8320136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8320136 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8320136 | pubmed:issn | 0198-8859 | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:Arnaiz-Villen... | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:MoralesPP | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:Martinez-Laso... | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:VarelaPP | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:BenmamarDD | lld:pubmed |
| pubmed-article:8320136 | pubmed:author | pubmed-author:BekhouchaFF | lld:pubmed |
| pubmed-article:8320136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8320136 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DRB1 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DQB1 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DQA1 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DRB | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DRB1*0801 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | DBR1*0806 | lld:pubmed |
| pubmed-article:8320136 | pubmed:geneSymbol | HLA-DRB1*0806 | lld:pubmed |
| pubmed-article:8320136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8320136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8320136 | pubmed:pagination | 172-8 | lld:pubmed |
| pubmed-article:8320136 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
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| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
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| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:meshHeading | pubmed-meshheading:8320136-... | lld:pubmed |
| pubmed-article:8320136 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8320136 | pubmed:articleTitle | Evolutionary relationships of HLA-DR8 alleles and description of a new subtype (DRB1*0806) in the Algerian population. | lld:pubmed |
| pubmed-article:8320136 | pubmed:affiliation | Department of Immunology, 12th of October Hospital, Complutense University, Madrid, Spain. | lld:pubmed |
| pubmed-article:8320136 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8320136 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8320136 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
