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pubmed-article:830914pubmed:abstractTextA child with recurrent pyogenic infections, eczema, markedly elevated serum concentrations IgA, and totally absent PMN chemotactic acticity is described. The chemotactic defect was characterized as a humoral inhibitor present in serumand plasma, directed toward autologous as well as homologous PMN's. Immunochemical studies revealed the purified inhibitor to be a cryoglobulin composed of an IgM-IgA complex. Incubation of the cryoglobulin complex with PMN's resulted in a quantitative dose-response curve.lld:pubmed
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pubmed-article:830914pubmed:articleTitlePMN chemotactic inhibition associated with a cryoglobulin.lld:pubmed
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