| pubmed-article:8304987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C0022956 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C1415104 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8304987 | lifeskim:mentions | umls-concept:C0251627 | lld:lifeskim |
| pubmed-article:8304987 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8304987 | pubmed:dateCreated | 1994-3-10 | lld:pubmed |
| pubmed-article:8304987 | pubmed:abstractText | S-p-Bromobenzylglutathione diethyl ester induced toxicity in the malarial parasite Plasmodium falciparum in infected human red blood cells in culture. The median inhibitory concentration, IC50, was 4.77 +/- 0.12 microM (N = 10) for incorporation of [3H]hypoxanthine in nucleotide synthesis and 5.20 +/- 0.1 microM (N = 10) for incorporation of [14C]isoleucine into protein. The prospective mechanism of action is inhibition of glyoxalase I by the de-esterified metabolite, S-p-bromobenzylglutathione, and accumulation of the cytotoxic substrate methylglyoxal. | lld:pubmed |
| pubmed-article:8304987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8304987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304987 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8304987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8304987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8304987 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8304987 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:8304987 | pubmed:author | pubmed-author:WilsonR JRJ | lld:pubmed |
| pubmed-article:8304987 | pubmed:author | pubmed-author:ThornalleyP... | lld:pubmed |
| pubmed-article:8304987 | pubmed:author | pubmed-author:StrathMM | lld:pubmed |
| pubmed-article:8304987 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8304987 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8304987 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:8304987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8304987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8304987 | pubmed:pagination | 418-20 | lld:pubmed |
| pubmed-article:8304987 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:8304987 | pubmed:meshHeading | pubmed-meshheading:8304987-... | lld:pubmed |
| pubmed-article:8304987 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8304987 | pubmed:articleTitle | Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester. | lld:pubmed |
| pubmed-article:8304987 | pubmed:affiliation | Department of Chemistry and Biological Chemistry, University of Essex, Colchester, U.K. | lld:pubmed |
| pubmed-article:8304987 | pubmed:publicationType | Journal Article | lld:pubmed |
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