| pubmed-article:8304411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8304411 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:8304411 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8304411 | lifeskim:mentions | umls-concept:C0024426 | lld:lifeskim |
| pubmed-article:8304411 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8304411 | pubmed:issue | 1 Pt 1 | lld:pubmed |
| pubmed-article:8304411 | pubmed:dateCreated | 1994-3-10 | lld:pubmed |
| pubmed-article:8304411 | pubmed:abstractText | The expression of cytocidal activity is initiated by the interaction of macrophages with priming [e.g., interferon (IFN)] and triggering stimuli (polyinosinic-polycytidylic acid). We have shown that the triggering step can be initiated in a Ca(2+)-dependent fashion and hypothesized that protein kinase C (PKC) may couple the Ca2+ signal to the expression of a gene product, Bf, that accompanies the expression of macrophage cytocidal activity. Exposure of IFN-primed macrophages to polyinosinic-polycytidylic acid in the presence of the PKC inhibitors H-7 or sphingosine or after downregulation of PKC with phorbol myristate acetate markedly inhibited Bf synthesis. Western blots of macrophage lysates revealed the presence of the alpha-, delta-, and zeta-isozymes of PKC, and all were found to be downregulated by phorbol myristate acetate. Inhibition of PKC also prevented the increase in IFN-beta mRNA levels and partially blocked the response to IFN-beta. These data suggest that the alpha-, delta-, and zeta-isozymes of PKC are involved in signaling leading to Bf expression and that the level of involvement is restricted to the induction and response to IFN-beta. | lld:pubmed |
| pubmed-article:8304411 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8304411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8304411 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8304411 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8304411 | pubmed:author | pubmed-author:DempseyE CEC | lld:pubmed |
| pubmed-article:8304411 | pubmed:author | pubmed-author:RichesD WDW | lld:pubmed |
| pubmed-article:8304411 | pubmed:author | pubmed-author:LakeF RFR | lld:pubmed |
| pubmed-article:8304411 | pubmed:author | pubmed-author:SpahnJ DJD | lld:pubmed |
| pubmed-article:8304411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8304411 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8304411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8304411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8304411 | pubmed:pagination | C134-42 | lld:pubmed |
| pubmed-article:8304411 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
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| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
| pubmed-article:8304411 | pubmed:meshHeading | pubmed-meshheading:8304411-... | lld:pubmed |
| pubmed-article:8304411 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8304411 | pubmed:articleTitle | Involvement of protein kinase C in macrophage activation by poly(I.C). | lld:pubmed |
| pubmed-article:8304411 | pubmed:affiliation | Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206. | lld:pubmed |
| pubmed-article:8304411 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8304411 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8304411 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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