| pubmed-article:8304244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C1519477 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C1819459 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C0205430 | lld:lifeskim |
| pubmed-article:8304244 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:8304244 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:8304244 | pubmed:dateCreated | 1994-3-7 | lld:pubmed |
| pubmed-article:8304244 | pubmed:abstractText | Prenatal exposure to diazepam leads to a suppression of mitogen or allogen-induced lymphocyte proliferation as well as to a reduced production of tumour necrosis factor (TNF)-alpha from rat splenocytes during postnatal development of rats. We analysed the secretion of interleukin (IL)-6 which occurs at a later stage of the cytokine cascade. Splenocytes of male offspring from Long Evans rats, treated with a daily dose of diazepam (1.25 mg/kg) from gestational day 14 to 20, were stimulated with lipopolysaccharide (LPS) and concanavalin A (Con A). In response to LPS, IL-6 liberation was significantly lower in mixed splenocytes and spleen macrophages of 2 and 8 week old prenatally diazepam-treated rats than in controls. Spleen lymphocyte preparations of prenatally treated animals exhibited a reduction of IL-6 release at 12 h and an increase at 24 h of incubation. At 2 weeks of age, Con A-induced IL-6 production could only be detected in mixed splenocytes; prenatally treated rats were releasing significantly less IL-6 than controls. In 8 week old rats, IL-6 liberation from mixed splenocytes and spleen macrophages was significantly lower in prenatally treated animals than in controls. Spleen lymphocytes presented a complex response picture depending upon incubation conditions. Our data indicate that in prenatally diazepam-exposed rats, the disturbance of cytokine release also extends to cytokines which play an important role in the later phases of immune responses. | lld:pubmed |
| pubmed-article:8304244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8304244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8304244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8304244 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8304244 | pubmed:issn | 0065-4299 | lld:pubmed |
| pubmed-article:8304244 | pubmed:author | pubmed-author:SchlumpfMM | lld:pubmed |
| pubmed-article:8304244 | pubmed:author | pubmed-author:FreiKK | lld:pubmed |
| pubmed-article:8304244 | pubmed:author | pubmed-author:Lichtensteige... | lld:pubmed |
| pubmed-article:8304244 | pubmed:author | pubmed-author:SchreiberA... | lld:pubmed |
| pubmed-article:8304244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8304244 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8304244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8304244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8304244 | pubmed:pagination | 166-73 | lld:pubmed |
| pubmed-article:8304244 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:meshHeading | pubmed-meshheading:8304244-... | lld:pubmed |
| pubmed-article:8304244 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8304244 | pubmed:articleTitle | Alterations in interleukin-6 production by LPS- and Con A-stimulated mixed splenocytes, spleen macrophages and lymphocytes in prenatally diazepam-exposed rats. | lld:pubmed |
| pubmed-article:8304244 | pubmed:affiliation | Institute of Pharmacology, University of Zurich, Switzerland. | lld:pubmed |
| pubmed-article:8304244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8304244 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8304244 | lld:pubmed |
