| pubmed-article:8302574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0887899 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8302574 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8302574 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8302574 | pubmed:dateCreated | 1994-3-4 | lld:pubmed |
| pubmed-article:8302574 | pubmed:abstractText | The Philadelphia chromosome, detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein, p210BCR-ABL, in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. To investigate p210BCR-ABL function we constructed a model system in which the tyrosine kinase activity of p210BCR-ABL was inducible. Two amino acid substitutions, Arg to His at amino acid 457 and Tyr to His at amino acid 469 of c-abl, modeled on mutations known to render v-src temperature-sensitive for tyrosine kinase activity, were introduced into p210BCR-ABL. This mutant was characterized in an IL-3 growth factor dependent murine myeloid cell line, 32Dc13. Cell lines expressing the temperature-sensitive mutant remained factor dependent at the non-permissive temperature, but at the permissive temperature displayed a marked reduction in cell death in the absence of growth factor and an exaggerated proliferative response to low levels of IL-3. Both the kinase activity of the mutant and the levels of tyrosine phosphorylated proteins are increased in the temperature-sensitive mutant at the permissive temperature. Further, tyrosine phosphorylation of potential substrates of the p210BCR-ABL tyrosine kinase, p120 rasGAP and its associated proteins of p190 and p62, only occurs at the permissive temperature in cells expressing the temperature-sensitive mutant. | lld:pubmed |
| pubmed-article:8302574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8302574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8302574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8302574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8302574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8302574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8302574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8302574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8302574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8302574 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8302574 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8302574 | pubmed:author | pubmed-author:GriffinJ DJD | lld:pubmed |
| pubmed-article:8302574 | pubmed:author | pubmed-author:DrukerB JBJ | lld:pubmed |
| pubmed-article:8302574 | pubmed:author | pubmed-author:CarlessoNN | lld:pubmed |
| pubmed-article:8302574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8302574 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8302574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8302574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8302574 | pubmed:pagination | 149-56 | lld:pubmed |
| pubmed-article:8302574 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8302574 | pubmed:meshHeading | pubmed-meshheading:8302574-... | lld:pubmed |
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| pubmed-article:8302574 | pubmed:meshHeading | pubmed-meshheading:8302574-... | lld:pubmed |
| pubmed-article:8302574 | pubmed:meshHeading | pubmed-meshheading:8302574-... | lld:pubmed |
| pubmed-article:8302574 | pubmed:meshHeading | pubmed-meshheading:8302574-... | lld:pubmed |
| pubmed-article:8302574 | pubmed:meshHeading | pubmed-meshheading:8302574-... | lld:pubmed |
| pubmed-article:8302574 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8302574 | pubmed:articleTitle | Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. | lld:pubmed |
| pubmed-article:8302574 | pubmed:affiliation | Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA. | lld:pubmed |
| pubmed-article:8302574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8302574 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8302574 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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