| pubmed-article:8299008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0009003 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0051169 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8299008 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8299008 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8299008 | pubmed:dateCreated | 1994-3-4 | lld:pubmed |
| pubmed-article:8299008 | pubmed:abstractText | Interleukin-1 is known to repress a number of hepatic drug-metabolizing enzymes in rats and humans. The effect of interleukin-1 beta on lauric acid 12-hydroxylase (CYP4A family) was studied in cultured fetal rat hepatocytes after clofibric acid induction. Dexamethasone was used as an agent promoting differentiation and long-term maintenance of active hepatocytes. Dexamethasone and clofibric acid in combination allowed maximal (13.5-fold) induction of CYP4A1. Lauric acid 12-hydroxylase activity was found to increase with time in culture. Interleukin-1 beta adversely affected P4504A clofibric acid-induced activity, totally eliminating the effect of induction at doses exceeding 5 ng/ml. This repression/inhibition was dose-dependent. The mechanism by which interleukin-1 beta prevents the development of cytochrome P4504A activity is unclear. | lld:pubmed |
| pubmed-article:8299008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8299008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8299008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8299008 | pubmed:issn | 0742-2091 | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:SiestGG | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:BattA MAM | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:GielenJ EJE | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:FerrariLL | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:KremersPP | lld:pubmed |
| pubmed-article:8299008 | pubmed:author | pubmed-author:ParmentierJ... | lld:pubmed |
| pubmed-article:8299008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8299008 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8299008 | pubmed:geneSymbol | CYP4A1 | lld:pubmed |
| pubmed-article:8299008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8299008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8299008 | pubmed:pagination | 307-13 | lld:pubmed |
| pubmed-article:8299008 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:meshHeading | pubmed-meshheading:8299008-... | lld:pubmed |
| pubmed-article:8299008 | pubmed:articleTitle | Repression of cytochrome P450 by cytokines: IL-1 beta counteracts clofibric acid induction of CYP4A in cultured fetal rat hepatocytes. | lld:pubmed |
| pubmed-article:8299008 | pubmed:affiliation | Centre du Médicament, URA CNRS 597, Université de Nancy I, France. | lld:pubmed |
| pubmed-article:8299008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8299008 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
