| pubmed-article:8287921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C1533685 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0027746 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:8287921 | lifeskim:mentions | umls-concept:C0283073 | lld:lifeskim |
| pubmed-article:8287921 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8287921 | pubmed:dateCreated | 1994-2-18 | lld:pubmed |
| pubmed-article:8287921 | pubmed:abstractText | In exploring the recently discovered phenomenon of indirect excitotoxicity, we noted that intrahippocampal injections of the nonspecific aminotransferase inhibitor gamma-acetylenic GABA (GAG; 60-240 nmol) caused excitotoxic lesions in rats. When assessed 3 days following the injection, GAG was shown to be approximately equally toxic to CA3/hilar neurons and CA1 pyramids, while CA2 neurons and granule cells were clearly less vulnerable. Choline acetyltransferase activity, a marker of extrinsic afferents, remained unchanged in the GAG-lesioned hippocampus, indicating the axon-sparing nature of the insult. In contrast, a lesion caused by 240 nmol of GAG resulted in a significant reduction in 3H-MK-801 binding, which was used as a marker for NMDA receptor-bearing hippocampal neurons. GAG-induced lesions were blocked by the NMDA receptor antagonists MK-801 and AP7 but were not influenced by the nature of the anesthetic used during surgery. Iontophoretic application of GAG did not excite CA1/CA3 cells in the rat hippocampus. In vitro, GAG proved to be a relatively potent inhibitor (IC50: 43 microM) of kynurenine aminotransferase, the biosynthetic enzyme of the endogenous neuroprotectant kynurenic acid. GAG also inhibited the neosynthesis of kynurenic acid in hippocampal slices (IC50: 790 microM). Thus, GAG shares several characteristics of the recently described indirect excitotoxin aminooxyacetic acid (AOAA; Exp. Neurol. 113: 378, 1991). GAG and AOAA appear to belong to a new family of excitotoxic agents which produce lesions indirectly by metabolic derangement and/or inhibition of kynurenate production. | lld:pubmed |
| pubmed-article:8287921 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8287921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8287921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8287921 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8287921 | pubmed:issn | 0014-4886 | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:SchwarczRR | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:FrenchE DED | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:BaratNN | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:LaiL WLW | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:WuH QHQ | lld:pubmed |
| pubmed-article:8287921 | pubmed:author | pubmed-author:McMasterO GOG | lld:pubmed |
| pubmed-article:8287921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8287921 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:8287921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8287921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8287921 | pubmed:pagination | 184-91 | lld:pubmed |
| pubmed-article:8287921 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8287921 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8287921 | pubmed:articleTitle | gamma-Acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus. | lld:pubmed |
| pubmed-article:8287921 | pubmed:affiliation | Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228. | lld:pubmed |
| pubmed-article:8287921 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8287921 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8287921 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
