| pubmed-article:8285624 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0004610 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0035608 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:8285624 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:8285624 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8285624 | pubmed:dateCreated | 1994-2-17 | lld:pubmed |
| pubmed-article:8285624 | pubmed:abstractText | Ten neonates with persistent staphylococcal bacteremia (positive blood cultures for > or = 5 days despite appropriate antibiotic therapy) received intravenous (i.v.) rifampin in combination with vancomycin with or without aminoglycoside. Their mean birth weight and length of gestation were 900 g and 27 weeks, respectively. Their ages at the time of infection ranged from 6 to 64 days (mean, 26 days). The staphylococcal isolates were methicillin-resistant Staphylococcus aureus (five isolates), methicillin-susceptible S. aureus (two isolates), and coagulase-negative staphylococci (three isolates). The mean number of bacteremia days prior to administration of i.v. rifampin was 8.3 (range, 5 to 15 days), despite a mean peak vancomycin concentration of 33 micrograms/ml. The dosing of rifampin varied from 2.5 to 10 mg/kg of body weight every 12 h. The mean duration of the rifampin course was 9.7 days (range, 3 to 16 days). Of the 10 neonates, 8 (80%) had sterile blood cultures within 24 h, 1 (10%) had a sterile blood culture within 48 h, and 1 (10%) had a sterile blood culture within 5 days of being placed on i.v. rifampin. No adverse effects were noted in this small group of infants. Seven of the 10 neonates survived; three died from unrelated complications. The MIC ranges of amikacin, vancomycin, and rifampin for the isolates were 2.0 to 16, 0.5 to 2.0, and 0.0013 to 0.04 micrograms/ml, respectively. We also studied eight infants, with a mean age of 23 days, who were receiving i.v. or oral rifampin at a dose of 10 mg/kg/day. For i.v. administration, the peak serum concentration of rifampin (mean +/- standard deviation) was 4.02 +/- 1.22 microgram/ml. The mean trough level at 12 h postifution was 1.11 +/- 0.48 micrograms/ml. For oral administration, the concentrations of rifampin in serum ranged from 0.59 to 2.86 micrograms/ml (mean, 1.86 +/- 0.96 microgram/ml) at 2 h postingestion, increasing to a peak concentration of 2.8 micrograms/ml at 8 h postingestion. The mean 12-h postingestion level was 0.77 +/- 0.03 microgram/ml. From the study of this limited series of neonates, rifampin appears to be a safe and effective addition to therapy when staphylococcal bacteremia is persistent despite vancomycin treatment. | lld:pubmed |
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| pubmed-article:8285624 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8285624 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8285624 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8285624 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8285624 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8285624 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:8285624 | pubmed:author | pubmed-author:RaoR RRR | lld:pubmed |
| pubmed-article:8285624 | pubmed:author | pubmed-author:KaplanS LSL | lld:pubmed |
| pubmed-article:8285624 | pubmed:author | pubmed-author:OuC NCN | lld:pubmed |
| pubmed-article:8285624 | pubmed:author | pubmed-author:MasonE OEOJr | lld:pubmed |
| pubmed-article:8285624 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8285624 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8285624 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8285624 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8285624 | pubmed:pagination | 2401-6 | lld:pubmed |
| pubmed-article:8285624 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8285624 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8285624 | pubmed:articleTitle | Use of intravenous rifampin in neonates with persistent staphylococcal bacteremia. | lld:pubmed |
| pubmed-article:8285624 | pubmed:affiliation | Department of Pediatrics, Baylor College of Medicine and Infectious Disease Laboratory, Texas Children's Hospital, Houston 77030. | lld:pubmed |
| pubmed-article:8285624 | pubmed:publicationType | Journal Article | lld:pubmed |
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