| pubmed-article:8284200 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8284200 | lifeskim:mentions | umls-concept:C0019353 | lld:lifeskim |
| pubmed-article:8284200 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:8284200 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:8284200 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8284200 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8284200 | pubmed:dateCreated | 1994-2-14 | lld:pubmed |
| pubmed-article:8284200 | pubmed:abstractText | The herpes simplex virus protein VP16 interacts with cellular factors, including the protein Oct-1, to activate viral immediate early (IE) gene transcription. We have reproduced this effect by addition of purified, full-length VP16 and the DNA-binding 'POU' domain of Oct-1 (Oct-1/POU) to a HeLa cell in vitro transcription system. Stimulation of transcription was dependent on the IE-specific element, TAATGARAT. In agreement with earlier observations from electrophoretic mobility shift assays, activation was not observed when Oct-2/POU, the DNA-binding domain from the Oct-2 protein, was substituted for Oct-1/POU. Single round transcription assays revealed that, together, VP16 and Oct-1/POU facilitate the assembly of pre-initiation complexes at target gene promoters. | lld:pubmed |
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| pubmed-article:8284200 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8284200 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8284200 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8284200 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8284200 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:SchaffnerWW | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:PrestonC MCM | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:ArnostiD NDN | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:LuisiB FBF | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:HagmannMM | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:HopeR GRG | lld:pubmed |
| pubmed-article:8284200 | pubmed:author | pubmed-author:LaughlanGG | lld:pubmed |
| pubmed-article:8284200 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8284200 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:8284200 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:8284200 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8284200 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8284200 | pubmed:pagination | 5570-6 | lld:pubmed |
| pubmed-article:8284200 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8284200 | pubmed:meshHeading | pubmed-meshheading:8284200-... | lld:pubmed |
| pubmed-article:8284200 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8284200 | pubmed:articleTitle | Specific transcriptional activation in vitro by the herpes simplex virus protein VP16. | lld:pubmed |
| pubmed-article:8284200 | pubmed:affiliation | Institut für Molekularbiologie II, Universitat Zürich, Switzerland. | lld:pubmed |
| pubmed-article:8284200 | pubmed:publicationType | Journal Article | lld:pubmed |
