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pubmed-article:8264320pubmed:abstractTextWe have used MR monitoring to guide and evaluate the effects of the Nd:YAG interstitial laser on a well-characterized rat brain tumor model (C6). MRI was used to determine the tumor size, verify the location of the interstitial probe, and evaluate the size and location of the laser-induced lesion during and after treatment. During laser irradiation, an irreversible loss of signal intensity at the fiber tip and a reversible decrease in signal intensity around it were observed with MRI. None of the treatment protocols affected mean rat survival significantly. Although MRI-guided interstitial laser therapy appears to be safe and easy, it does not provide a curative treatment for spatially disseminated gliomas where a "target volume" cannot be adequately defined. Better results can be expected, especially in well-defined tumors, with improvements of both the imaging techniques and the laser treatment protocol.lld:pubmed
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pubmed-article:8264320pubmed:authorpubmed-author:HushekS GSGlld:pubmed
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pubmed-article:8264320pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:8264320pubmed:articleTitleMRI guided interstitial laser therapy in a rat malignant glioma model.lld:pubmed
pubmed-article:8264320pubmed:affiliationDepartment of Neurosurgery, Children's Hospital, Boston, Massachusetts.lld:pubmed
pubmed-article:8264320pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8264320pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:8264320pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed