| pubmed-article:8261458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0017817 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0017837 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8261458 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8261458 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8261458 | pubmed:dateCreated | 1994-1-21 | lld:pubmed |
| pubmed-article:8261458 | pubmed:abstractText | Induction of glutathione S-transferase Ya and NAD(P)H:quinone reductase gene expression by a variety of chemical agents is mediated by regulatory elements, EpRE and ARE, composed of two adjacent AP-1-like binding sites and activated by Fos/Jun heterodimeric complex (AP-1). Recent studies show that chemical induction of glutathione S transferase Ya and quinone reductase gene expression is associated with an induction of c-fos and c-jun gene expression and AP-1 binding activity. In this report we present evidence that the AP-1 binding activity and the expression of chloramphenicol acetyltransferase activity from an EpRE Ya-cat gene construct are induced by an increase in intracellular oxidant levels. We observe that lowering the glutathione levels with buthionine sulfoximine, an inhibitor of gamma-glutamylcysteine synthetase, or diamide, a thiol-oxidizing agent, stimulates both basal and chemical-inducible expression of chloramphenicol acetyltransferase activity from EpRE Ya-cat and the AP-1 binding activity. Furthermore, we observe that the induction of these activities by a variety of chemical agents is inhibited by thiol compounds N-acetylcysteine and glutathione. These findings suggest that diverse chemicals that induce the AP-1 complex, leading to the AP-1-mediated transcriptional activation of glutathione S-transferase Ya gene expression, may act through a common mechanism involving the production of reactive oxygen species and depletion of reduced glutathione. | lld:pubmed |
| pubmed-article:8261458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8261458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8261458 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8261458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8261458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8261458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8261458 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8261458 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8261458 | pubmed:author | pubmed-author:DanielVV | lld:pubmed |
| pubmed-article:8261458 | pubmed:author | pubmed-author:PinkusRR | lld:pubmed |
| pubmed-article:8261458 | pubmed:author | pubmed-author:BergelsonSS | lld:pubmed |
| pubmed-article:8261458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8261458 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8261458 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:8261458 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:8261458 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:8261458 | pubmed:geneSymbol | Ya-cat | lld:pubmed |
| pubmed-article:8261458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8261458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8261458 | pubmed:pagination | 36-40 | lld:pubmed |
| pubmed-article:8261458 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8261458 | pubmed:meshHeading | pubmed-meshheading:8261458-... | lld:pubmed |
| pubmed-article:8261458 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8261458 | pubmed:articleTitle | Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression. | lld:pubmed |
| pubmed-article:8261458 | pubmed:affiliation | Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel. | lld:pubmed |
| pubmed-article:8261458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8261458 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8261458 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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