| pubmed-article:8258338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C1416831 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8258338 | lifeskim:mentions | umls-concept:C0439098 | lld:lifeskim |
| pubmed-article:8258338 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8258338 | pubmed:dateCreated | 1994-1-14 | lld:pubmed |
| pubmed-article:8258338 | pubmed:abstractText | Macrophage cell-surface protein 2 (Mac-2), a galactose specific S-type lectin identified in inflammatory macrophages, presents a high degree of homology with the rat IgE-binding protein (epsilon BP). In the present study, we show by different experimental approaches that human eosinophils can express Mac-2/epsilon BP. Flow cytometry analysis revealed that a large proportion of eosinophilic patients expressing binding sites for IgE on their eosinophil membrane, were able to bind anti-Mac-2 monoclonal antibody (mAb). Northern blot performed with eosinophil RNA hybridized with the human Mac-2 or epsilon BP cDNA probes revealed that eosinophils presented a unique transcript at 1.2 kb. Immunoprecipitation of eosinophil extracts with anti-Mac-2 mAb revealed the presence of a molecule of 29 kDa corresponding to Mac-2 protein, as well as one additional molecule of 15 kDa, absent from control alveolar macrophages. The function of these molecules was investigated in a radiolabeled IgE binding assay. Anti-Mac-2 mAb as well as galactose and lactose saccharides significantly inhibited the binding of radiolabeled human myeloma IgE protein to eosinophils. Moreover, the dose-dependent inhibition by anti-Mac-2 mAb of IgE-dependent eosinophil-mediated cytotoxicity towards parasite targets indicated the role of these IgE-binding molecules in the function of human eosinophils. These results suggest that in addition to transmembrane receptors, lectin-type molecules can participate in the IgE-dependent effector function of eosinophils. | lld:pubmed |
| pubmed-article:8258338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8258338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8258338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8258338 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8258338 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:CapronAA | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:LinF MFM | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:CapronMM | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:PrinLL | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:GruartVV | lld:pubmed |
| pubmed-article:8258338 | pubmed:author | pubmed-author:TruongM JMJ | lld:pubmed |
| pubmed-article:8258338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8258338 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:8258338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8258338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8258338 | pubmed:pagination | 3230-5 | lld:pubmed |
| pubmed-article:8258338 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
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| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:meshHeading | pubmed-meshheading:8258338-... | lld:pubmed |
| pubmed-article:8258338 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8258338 | pubmed:articleTitle | IgE-binding molecules (Mac-2/epsilon BP) expressed by human eosinophils. Implication in IgE-dependent eosinophil cytotoxicity. | lld:pubmed |
| pubmed-article:8258338 | pubmed:affiliation | Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167--CNRS 624, Institut Pasteur, Lille, France. | lld:pubmed |
| pubmed-article:8258338 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8258338 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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