| pubmed-article:8252622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C1160421 | lld:lifeskim |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8252622 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8252622 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8252622 | pubmed:dateCreated | 1994-1-10 | lld:pubmed |
| pubmed-article:8252622 | pubmed:abstractText | During C. elegans development, the temporal pattern of many cell lineages is specified by graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4. The lin-14 3'UTR is both necessary and sufficient to confer lin-4-mediated posttranscriptional temporal regulation. The function of the lin-14 3'UTR is conserved between C. elegans and C. briggsae. Among the conserved sequences are seven elements that are each complementary to the lin-4 RNAs. A reporter gene bearing three of these elements shows partial temporal gradient activity. These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation. | lld:pubmed |
| pubmed-article:8252622 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8252622 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8252622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8252622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8252622 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8252622 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:8252622 | pubmed:author | pubmed-author:HOWW | lld:pubmed |
| pubmed-article:8252622 | pubmed:author | pubmed-author:RuvkunGG | lld:pubmed |
| pubmed-article:8252622 | pubmed:author | pubmed-author:WightmanBB | lld:pubmed |
| pubmed-article:8252622 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8252622 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:8252622 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:8252622 | pubmed:geneSymbol | lin-14 | lld:pubmed |
| pubmed-article:8252622 | pubmed:geneSymbol | lin-4 | lld:pubmed |
| pubmed-article:8252622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8252622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8252622 | pubmed:pagination | 855-62 | lld:pubmed |
| pubmed-article:8252622 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
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| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:meshHeading | pubmed-meshheading:8252622-... | lld:pubmed |
| pubmed-article:8252622 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8252622 | pubmed:articleTitle | Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. | lld:pubmed |
| pubmed-article:8252622 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:8252622 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8252622 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8252622 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8252622 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:266860 | entrezgene:pubmed | pubmed-article:8252622 | lld:entrezgene |
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