| pubmed-article:8246241 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8246241 | lifeskim:mentions | umls-concept:C0058698 | lld:lifeskim |
| pubmed-article:8246241 | lifeskim:mentions | umls-concept:C0005029 | lld:lifeskim |
| pubmed-article:8246241 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:8246241 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:8246241 | pubmed:dateCreated | 1994-1-6 | lld:pubmed |
| pubmed-article:8246241 | pubmed:abstractText | Two series of (N-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3 beta-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and alpha 2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity needed for in vivo studies of the D2 (and possibly D3) receptors. 18F-Labeled analogues of 23, 26b and 34 were prepared by N-alkylation of the corresponding desbenzyl precursors with [18F]-4-fluorobenzyl iodide. Preliminary in vivo studies demonstrated that [18F]-23 and [18F]-26b are suitable candidates for further evaluation in positron emission tomography imaging studies. The slow rate of washout of [18F]-34 from nondopaminergic regions and its comparatively high lipophilicity indicates that this compound may not be suitable for imaging studies because of a high level of nonspecific binding. | lld:pubmed |
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| pubmed-article:8246241 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8246241 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8246241 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8246241 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8246241 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8246241 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8246241 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8246241 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8246241 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:HoffmanP LPL | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:ElderS TST | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:JacksonJ RJR | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:MackR MRM | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:UnsworthC DCD | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:LuedtkeR RRR | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:NowakP APA | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:BoundyV AVA | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:EvoraP HPH | lld:pubmed |
| pubmed-article:8246241 | pubmed:author | pubmed-author:ScripkoJ GJG | lld:pubmed |
| pubmed-article:8246241 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8246241 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:8246241 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8246241 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8246241 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8246241 | pubmed:pagination | 3707-20 | lld:pubmed |
| pubmed-article:8246241 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8246241 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8246241 | pubmed:articleTitle | 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. | lld:pubmed |
| pubmed-article:8246241 | pubmed:affiliation | Cerebrovascular Research Center, University of Pennsylvania, Philadelphia 19104. | lld:pubmed |
| pubmed-article:8246241 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8246241 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:8246241 | lld:chembl |
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