| pubmed-article:8244009 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C1166670 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C0039290 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C0017404 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C0010366 | lld:lifeskim |
| pubmed-article:8244009 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:8244009 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8244009 | pubmed:dateCreated | 1994-1-6 | lld:pubmed |
| pubmed-article:8244009 | pubmed:abstractText | The Responder (Rsp) locus in Drosophila melanogaster is the target locus of segregation distortion and is known to be comprised of a tandem array of 120-bp repetitive sequences. In this study, we first determined the large scale molecular structure of the Rsp locus, which extends over a region of 600 kb on the standard sensitive (cn bw) chromosome. Within the region, small Rsp repeat arrays are interspersed with non-Rsp sequences and account for 10-20% of the total sequences. We isolated and sequenced 32 Rsp clones from three different chromosomes. The main results are: (1) Rsp repeats isolated from the same chromosome are not more similar than those from different chromosomes. This implies either that there are more homologous exchanges at the Rsp locus than expected or, alternatively, that the second chromosomes of D. melanogaster have diverged from one another more recently at the centromeric heterochromatin than at the nearby euchromatin. (2) The repeats usually have a dimeric structure with an average difference of 16% between the left and right halves. The differences allow us to easily identify the products of unequal exchanges. Despite the large differences between the two halves, exchanges have occurred frequently and the majority of them fall within a 29-bp interval of identity between the two halves. Our data thus support the suggestion that recombination depends on short stretches of complete identity rather than long stretches of general homology. (3) Frequent unequal crossover events obscure the phylogenetic relationships between repeats; therefore, different parts of any single repeat could often have different phylogenetic histories. The high rate of unequal crossing over may also help explain the evolutionary dynamics of the Rsp locus. | lld:pubmed |
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| pubmed-article:8244009 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8244009 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8244009 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8244009 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8244009 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8244009 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:8244009 | pubmed:author | pubmed-author:WuC ICI | lld:pubmed |
| pubmed-article:8244009 | pubmed:author | pubmed-author:CabotE LEL | lld:pubmed |
| pubmed-article:8244009 | pubmed:author | pubmed-author:DoshiPP | lld:pubmed |
| pubmed-article:8244009 | pubmed:author | pubmed-author:WuM LML | lld:pubmed |
| pubmed-article:8244009 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8244009 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:8244009 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8244009 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8244009 | pubmed:pagination | 477-87 | lld:pubmed |
| pubmed-article:8244009 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:8244009 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8244009 | pubmed:articleTitle | Population genetics of tandem repeats in centromeric heterochromatin: unequal crossing over and chromosomal divergence at the Responder locus of Drosophila melanogaster. | lld:pubmed |
| pubmed-article:8244009 | pubmed:affiliation | Department of Ecology and Evolution, University of Chicago, Illinois 60637. | lld:pubmed |
| pubmed-article:8244009 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8244009 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8244009 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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