| pubmed-article:8239593 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8239593 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8239593 | lifeskim:mentions | umls-concept:C1264633 | lld:lifeskim |
| pubmed-article:8239593 | lifeskim:mentions | umls-concept:C0030895 | lld:lifeskim |
| pubmed-article:8239593 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8239593 | pubmed:dateCreated | 1993-12-16 | lld:pubmed |
| pubmed-article:8239593 | pubmed:abstractText | Sodium stibogluconate, a pentavalent antimony derivative produced by the reaction of stibonic and gluconic acids, is the drug of choice for the treatment of leishmaniasis. It has been reported to be a complex mixture rather than a single compound. We separated sodium stibogluconate into 12 fractions by anion-exchange chromatography. One fraction accounted for virtually all the leishmanicidal activity of the fractionated material against Leishmania panamensis promastigotes, with a 50% inhibitory concentration (IC50) of 12 micrograms of Sb per ml; that of unfractionated sodium stibogluconate was 154 micrograms of Sb per ml. Further analysis of this active fraction revealed that a major component was m-chlorocresol, which had been included in the sodium stibogluconate formulation as a preservative. The IC50 of pure m-chlorocresol was 1.6 micrograms/ml, a concentration equivalent to that present in unfractionated sodium stibogluconate at a concentration of 160 micrograms of Sb per ml. After ether extraction to remove m-chlorocresol, the IC50 of sodium stibogluconate was > 4,000 micrograms of Sb per ml. In contrast, when L. panamensis amastigotes were grown in macrophages, the IC50 of ether-extracted sodium stibogluconate was 10.3 micrograms of Sb per ml. The 12 fractions of ether-extracted sodium stibogluconate obtained by anion-exchange chromatography had IC50s of 10.1 to 15.4 micrograms of Sb per ml. We conclude that preservative-free sodium stibogluconate has little activity against L. panamensis promastigotes but is highly active against L. panamensis amastigotes in macrophages. This activity is associated with multiple chemical species. | lld:pubmed |
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| pubmed-article:8239593 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8239593 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8239593 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8239593 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8239593 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8239593 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:8239593 | pubmed:author | pubmed-author:RobertsW LWL | lld:pubmed |
| pubmed-article:8239593 | pubmed:author | pubmed-author:RaineyP MPM | lld:pubmed |
| pubmed-article:8239593 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8239593 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8239593 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8239593 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8239593 | pubmed:pagination | 1842-6 | lld:pubmed |
| pubmed-article:8239593 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8239593 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8239593 | pubmed:articleTitle | Antileishmanial activity of sodium stibogluconate fractions. | lld:pubmed |
| pubmed-article:8239593 | pubmed:affiliation | Department of Laboratory Medicine, Yale University, New Haven, Connecticut 06510. | lld:pubmed |
| pubmed-article:8239593 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8239593 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8239593 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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