| pubmed-article:8234266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C0325174 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C0108555 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8234266 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8234266 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:8234266 | pubmed:dateCreated | 1993-12-9 | lld:pubmed |
| pubmed-article:8234266 | pubmed:abstractText | An Epstein-Barr virus-encoded protein, ZEBRA, mediates the switch from latency to the viral lytic life cycle. ZEBRA's domain structure and DNA binding specificity resemble that of cellular transcriptional activators such as c-Fos/c-Jun. We show that ZEBRA, like c-Jun, is phosphorylated by casein kinase II (CKII). The principal site of phosphorylation is serine-173 (S173), five amino acids upstream of the basic DNA recognition domain. CKII phosphorylation abrogated ZEBRA's capacity to bind its target DNA sequences. S173 is a functional component of ZEBRA's DNA binding domain, since mutation of S173 to alanine (S173A) reduced DNA binding in vitro to 10% of wild-type levels. Transcriptional activation of a native viral promoter in vivo by mutant S173A was also reduced markedly. Reversible phosphorylation of S173 is likely to be an important means of regulating ZEBRA's activity in vivo. | lld:pubmed |
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| pubmed-article:8234266 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8234266 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8234266 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8234266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8234266 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8234266 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8234266 | pubmed:author | pubmed-author:MillerGG | lld:pubmed |
| pubmed-article:8234266 | pubmed:author | pubmed-author:TaylorNN | lld:pubmed |
| pubmed-article:8234266 | pubmed:author | pubmed-author:MarshakD RDR | lld:pubmed |
| pubmed-article:8234266 | pubmed:author | pubmed-author:KolmanJ LJL | lld:pubmed |
| pubmed-article:8234266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8234266 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8234266 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8234266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8234266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8234266 | pubmed:pagination | 10115-9 | lld:pubmed |
| pubmed-article:8234266 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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