| pubmed-article:8228801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8228801 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:8228801 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8228801 | pubmed:dateCreated | 1993-11-29 | lld:pubmed |
| pubmed-article:8228801 | pubmed:abstractText | Interleukin 10 (IL-10) has recently been shown to induce normal human B lymphocytes to proliferate and differentiate into immunoglobulin (Ig)-secreting cells. Herein, we show that IL-10 also promotes DNA synthesis and IgM production by anti-CD40 activated B cell chronic lymphocytic leukemia (B-CLL). Most strikingly, IL-2 and IL-10 were found to synergize to induce the proliferation and differentiation of B-CLL cells. This synergy between IL-2 and IL-10 was also observed with normal B cells which proliferated strongly and secreted large amounts of IgM, IgG, and IgA. The observed synergy is likely to be due to the IL-10-induced increase of high affinity IL-2 receptors on both normal and leukemic B cells. This increase of high affinity receptor is associated to an increase of Tac/CD25 expression that can be detected by flow cytometric analysis. Taken together, these results indicate that IL-10 permits anti-CD40 activated B cells to respond to IL-2 through an induction of high affinity IL-2 receptors. This effect of IL-10 may partly explain how T cells, which activate B cells in a CD40-dependent fashion, induce B cell proliferation and differentiation mostly through IL-2. | lld:pubmed |
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| pubmed-article:8228801 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8228801 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8228801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8228801 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8228801 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8228801 | pubmed:author | pubmed-author:BanchereauJJ | lld:pubmed |
| pubmed-article:8228801 | pubmed:author | pubmed-author:DurandII | lld:pubmed |
| pubmed-article:8228801 | pubmed:author | pubmed-author:FluckigerA... | lld:pubmed |
| pubmed-article:8228801 | pubmed:author | pubmed-author:GalizziJ PJP | lld:pubmed |
| pubmed-article:8228801 | pubmed:author | pubmed-author:GarronePP | lld:pubmed |
| pubmed-article:8228801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8228801 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8228801 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:8228801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8228801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8228801 | pubmed:pagination | 1473-81 | lld:pubmed |
| pubmed-article:8228801 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8228801 | pubmed:meshHeading | pubmed-meshheading:8228801-... | lld:pubmed |
| pubmed-article:8228801 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8228801 | pubmed:articleTitle | Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. | lld:pubmed |
| pubmed-article:8228801 | pubmed:affiliation | Laboratory for Immunological Research, Schering-Plough, Dardilly, France. | lld:pubmed |
| pubmed-article:8228801 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8228801 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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