| pubmed-article:8223936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0205527 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0064239 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0073631 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:8223936 | lifeskim:mentions | umls-concept:C0068961 | lld:lifeskim |
| pubmed-article:8223936 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8223936 | pubmed:dateCreated | 1993-12-16 | lld:pubmed |
| pubmed-article:8223936 | pubmed:abstractText | Systemic and intrathecally administered ketorolac produced antinociception in the p-phenylquinone test, but not in the tail-flick or hot-plate tests. Antagonists of the subtypes of opioid receptors were used to evaluate the interaction of ketorolac with these receptors. Intrathecally administered kappa-opioid receptor antagonist nor-binaltorphimine dihydrochloride blocked the antinociceptive effects of systemic ketorolac and intrathecally administered ketorolac. Naloxone and ICI 174,864 failed to block the effects of ketorolac. Activation of nor-binaltorphimine-sensitive receptors appears to be an integral element in the mechanism of antinociception of ketorolac at the spinal level. Ketorolac did not precipitate withdrawal jumping in morphine-tolerant mice demonstrating that ketorolac does not act as a mixed agonist-antagonist at the opioid receptor. We suggest that neuraxial placement of ketorolac may prove useful in the clinical setting for the management of acute pain in humans. | lld:pubmed |
| pubmed-article:8223936 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8223936 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8223936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8223936 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8223936 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8223936 | pubmed:author | pubmed-author:EllisE FEF | lld:pubmed |
| pubmed-article:8223936 | pubmed:author | pubmed-author:WelchS PSP | lld:pubmed |
| pubmed-article:8223936 | pubmed:author | pubmed-author:WardC RCR | lld:pubmed |
| pubmed-article:8223936 | pubmed:author | pubmed-author:UphouseL ALA | lld:pubmed |
| pubmed-article:8223936 | pubmed:author | pubmed-author:EmbreyJ PJP | lld:pubmed |
| pubmed-article:8223936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8223936 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:8223936 | pubmed:volume | 242 | lld:pubmed |
| pubmed-article:8223936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8223936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8223936 | pubmed:pagination | 53-8 | lld:pubmed |
| pubmed-article:8223936 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8223936 | pubmed:meshHeading | pubmed-meshheading:8223936-... | lld:pubmed |
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| pubmed-article:8223936 | pubmed:meshHeading | pubmed-meshheading:8223936-... | lld:pubmed |
| pubmed-article:8223936 | pubmed:meshHeading | pubmed-meshheading:8223936-... | lld:pubmed |
| pubmed-article:8223936 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8223936 | pubmed:articleTitle | Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine. | lld:pubmed |
| pubmed-article:8223936 | pubmed:affiliation | Department of Nurse Anesthesia, MCV Station, Richmond 23298-0226. | lld:pubmed |
| pubmed-article:8223936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8223936 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8223936 | lld:pubmed |
