| pubmed-article:8223459 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0007597 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0020200 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C1882263 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C0679079 | lld:lifeskim |
| pubmed-article:8223459 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:8223459 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8223459 | pubmed:dateCreated | 1993-12-21 | lld:pubmed |
| pubmed-article:8223459 | pubmed:abstractText | The Oct-3 gene is expressed in highly undifferentiated cells and is implicated in mammalian early embryogenesis. We have generated a series of hybrid cells between pluripotent embryonal carcinoma cells (Oct-3+) and fibroblasts (Oct-3-), and have studied the regulation and function of Oct-3. Upon fusion, the hybrid cells differentiated to nestin+/Brn-2+ cells resembling neuroepithelial stem cells. Expression of Oct-3 was extinguished at the transcriptional level in all the hybrid cells examined. The Oct-3 modulating activity required for the Oct-3-mediated enhancer activation was also extinguished. When the Oct-3 transactivating function was introduced into the hybrid cells, they transformed into morphologically distinct nestin-/Brn-2- cells ('revertants'). When the 'revertant' cells subsequently lost Oct-3 expression, they differentiated back to nestin+/Brn-2+ cells. The close correlation between the phenotypic changes and the gain/loss of Oct-3 function indicates that Oct-3 can induce dedifferentiation of the neural cells. | lld:pubmed |
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| pubmed-article:8223459 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8223459 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8223459 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8223459 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8223459 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:FujiiHH | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:IkedaMM | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:HamadaHH | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:MuramatsuMM | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:McKayR DRD | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:TamaiKK | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:OkazawaHH | lld:pubmed |
| pubmed-article:8223459 | pubmed:author | pubmed-author:ShimazakiTT | lld:pubmed |
| pubmed-article:8223459 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8223459 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8223459 | pubmed:geneSymbol | Oct-3 | lld:pubmed |
| pubmed-article:8223459 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8223459 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8223459 | pubmed:pagination | 4489-98 | lld:pubmed |
| pubmed-article:8223459 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8223459 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8223459 | pubmed:articleTitle | Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential. | lld:pubmed |
| pubmed-article:8223459 | pubmed:affiliation | Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:8223459 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8223459 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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