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| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0019638 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0019829 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0037995 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0751623 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0284965 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:8217588 | lifeskim:mentions | umls-concept:C0015737 | lld:lifeskim |
| pubmed-article:8217588 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8217588 | pubmed:dateCreated | 1993-12-7 | lld:pubmed |
| pubmed-article:8217588 | pubmed:abstractText | The risks of second primary cancer were analysed in 2846 patients with Hodgkin's disease treated within the British National Lymphoma Investigation during 1970-87. The relative risk (RR) of leukaemia was significantly greater in women (RR = 30.1; 95% confidence limits (CL) 13.0-59.5) than in men (RR = 10.9; 95% CL 4.7-21.5), and showed a significant trend of greater risk with younger age at first treatment (P < 0.001). The relative risk of solid cancers was similar between the sexes, but again significantly greater at young than at older ages of first treatment (P < 0.01). Non-Hodgkin's lymphoma relative risks, although not related to sex or age, were significantly related to histology of the original Hodgkin's disease, and were greatest after lymphocyte predominant Hodgkin's disease (RR = 55.6; 95% CL 18.0-129.7). The relative risk of second cancers did not vary significantly according to whether or not splenectomy had been performed. Leukaemia risk was non-significantly greater after splenectomy than with no splenectomy, which accorded with previous evidence of a modest increased risk associated with this operation. If the greater relative risk of solid second cancers after treatment at young than at older ages persists with longer follow-up, the incidence rates of these second primaries in patients treated young for Hodgkin's disease will become very substantial as they age. This emphasises the need to maintain long-term follow-up surveillance of young Hodgkin's disease patients apparently cured of their disease, and to continue to develop new less carcinogenic treatment regimens. | lld:pubmed |
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| pubmed-article:8217588 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8217588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8217588 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8217588 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8217588 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8217588 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8217588 | pubmed:author | pubmed-author:SwerdlowA JAJ | lld:pubmed |
| pubmed-article:8217588 | pubmed:author | pubmed-author:DouglasA JAJ | lld:pubmed |
| pubmed-article:8217588 | pubmed:author | pubmed-author:MacLennanK... | lld:pubmed |
| pubmed-article:8217588 | pubmed:author | pubmed-author:Vaughan... | lld:pubmed |
| pubmed-article:8217588 | pubmed:author | pubmed-author:Vaughan... | lld:pubmed |
| pubmed-article:8217588 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8217588 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:8217588 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8217588 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8217588 | pubmed:pagination | 1006-11 | lld:pubmed |
| pubmed-article:8217588 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8217588 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8217588 | pubmed:articleTitle | Risk of second primary cancer after Hodgkin's disease in patients in the British National Lymphoma Investigation: relationships to host factors, histology and stage of Hodgkin's disease, and splenectomy. | lld:pubmed |
| pubmed-article:8217588 | pubmed:affiliation | Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK. | lld:pubmed |
| pubmed-article:8217588 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8217588 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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