| pubmed-article:8215438 | pubmed:abstractText | The effect of the association of alpha-tocopherol (vitamin E) with single chain or very asymmetric phospholipids has been studied by 31P nuclear magnetic resonance, Fourier transform infrared spectroscopy, and light microscopy. Our results demonstrate that alpha-tocopherol stabilizes and forms bilayer structures in systems composed of either 1-palmitoyl-sn-glycero-3-phosphocholine, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-hexadecyl-sn-glycero-3-phosphocholine, or 1,2-dipalmitoyl-sn-glycero-3- phosphocholine/1-palmitoyl-sn-glycero-3-phosphocholine, whereas in the absence of alpha-tocopherol all these systems produce micellar structures. The free hydroxyl group of alpha-tocopherol is shown to be important in stabilizing the bilayer structure by comparing the effects produced by an analog of alpha-tocopherol, alpha-tocopheryl acetate, which has the hydroxyl group blocked by an acetyl group. It is suggested that the complementary shapes of alpha-tocopherol and the asymmetric phospholipids may be the reason for the stabilization of the bilayer structure. | lld:pubmed |
