| pubmed-article:8206520 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0521066 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0018893 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0506994 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0026682 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0018889 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:8206520 | lifeskim:mentions | umls-concept:C0321331 | lld:lifeskim |
| pubmed-article:8206520 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8206520 | pubmed:dateCreated | 1994-7-11 | lld:pubmed |
| pubmed-article:8206520 | pubmed:abstractText | The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus brasiliensis adult worms obtained from donor rats at 7 ('normal' worms) or 13 days ('damaged' worms) post-infection were implanted intraduodenally into euthymic and hypothymic (rnu/rnu) rats. Expulsion of implanted normal worms and associated goblet cell changes were extremely delayed in hypothymic recipients compared with euthymic recipients. In contrast, intraduodenally implanted damaged worms were expelled by day 5 regardless of the strains. Around the time of expulsion of implanted damaged worms, euthymic recipients showed both goblet cell hyperplasia and alteration of mucins, whereas hypothymic rats showed only the latter. Dexamethasone treatment completely abolished goblet cell changes of both strains of recipients. To clarify the importance of the constitutional changes of goblet cell mucins in mucosal defence, euthymic rats were primed by implantation of damaged worms to induce goblet cell changes, and then 3 or 5 days later they were challenged by implantation with normal worms. The results show that when goblet cell changes were induced by priming with damaged worms, recipient rats could completely prevent the establishment of normal worms. When hypothymic rats were primed and challenged in the same manner, a similar but slightly less preventive effect was observed. Such a protective effect of altered mucins seems to be selective because priming of euthymic rats with damaged N. brasiliensis did not affect the establishment of Strongyloides venezuelensis. These results suggest that: (1) once N. brasiliensis adult worms are 'damaged' by the host's T-cell-dependent immune mechanisms, they can induce alteration of sugar residues of goblet cell mucins via host-mediated, T-cell-independent processes; (2) the expression of such altered mucins is highly effective not only in causing expulsion of established damaged worms but also in preventing establishment of normal worms; and (3) the preventive effect of altered mucins is selective against parasite species. | lld:pubmed |
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| pubmed-article:8206520 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8206520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8206520 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8206520 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8206520 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8206520 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8206520 | pubmed:author | pubmed-author:NawaYY | lld:pubmed |
| pubmed-article:8206520 | pubmed:author | pubmed-author:SuganumaTT | lld:pubmed |
| pubmed-article:8206520 | pubmed:author | pubmed-author:IshikawaNN | lld:pubmed |
| pubmed-article:8206520 | pubmed:author | pubmed-author:HoriiYY | lld:pubmed |
| pubmed-article:8206520 | pubmed:author | pubmed-author:OinumaTT | lld:pubmed |
| pubmed-article:8206520 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8206520 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:8206520 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8206520 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8206520 | pubmed:pagination | 480-6 | lld:pubmed |
| pubmed-article:8206520 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8206520 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8206520 | pubmed:articleTitle | Goblet cell mucins as the selective barrier for the intestinal helminths: T-cell-independent alteration of goblet cell mucins by immunologically 'damaged' Nippostrongylus brasiliensis worms and its significance on the challenge infection with homologous and heterologous parasites. | lld:pubmed |
| pubmed-article:8206520 | pubmed:affiliation | Department of Parasitology, Miyazaki Medical College, Japan. | lld:pubmed |
| pubmed-article:8206520 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8206520 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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