Linked Life Data

8206321

Source:http://linkedlifedata.com/resource/pubmed/id/8206321

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pubmed-article:8206321pubmed:abstractTextTransforming growth factor-beta (TGF-beta) was found to inhibit basal and ACTH-stimulated steroid production by cultured human fetal adrenal cells. The inhibitory effects of TGF-beta were both time and dose-dependent. Inhibition of basal dehydroepiandrosterone sulfate (DS) production usually was noted only after 3 or more days of treatment with > or = 0.1 ng TGF-beta/ml. The inhibitory effects of 1 ng/ml TGF-beta on ACTH-stimulated DS production were more striking than those on cortisol production by both fetal zone and neocortical cells. TGF-beta also was found to interfere with DS and cortisol production by fetal zone cells in response to forskolin and dibutyryl cAMP. TGF-beta interfered with ACTH stimulation of cytochrome P450(17) alpha mRNA in fetal zone and neocortex cells. These results are suggestive that TGF-beta differentially inhibits DS and cortisol production by human fetal adrenal cells and that the site of TGF-beta action on steroidogenesis may be distal to the generation of cAMP. Such results, along with those of others, are suggestive that TGF-beta may play an autocrine/paracrine role in the human adrenal.lld:pubmed
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pubmed-article:8206321pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8206321pubmed:year1994lld:pubmed
pubmed-article:8206321pubmed:articleTitleEffects of transforming growth factor-beta on human fetal adrenal steroid production.lld:pubmed
pubmed-article:8206321pubmed:affiliationDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.lld:pubmed
pubmed-article:8206321pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8206321pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:8206321pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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