| pubmed-article:8197198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0015502 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0021107 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C1524066 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C1552302 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C1552291 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:8197198 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8197198 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8197198 | pubmed:dateCreated | 1994-6-27 | lld:pubmed |
| pubmed-article:8197198 | pubmed:abstractText | Hemophilia A is caused by defects in the factor VIII gene. This results in life-threatening hemorrhages and severe arthropathies. Today, hemophiliacs are treated with human blood-derived factor VIII. In the future, it may be possible to use gene therapy to avoid long-term complications of conventional therapy and to improve the quality of life. However, initial gene therapy models using retroviral vectors and nonviral gene transfer techniques to introduce factor VIII gene constructs have been hampered by low expression levels of factor VIII. We show here that high expression levels of the B-domain-deleted human factor VIII in primary mouse fibroblasts and myoblasts are obtained by using receptor-mediated, adenovirus-augmented gene delivery (transferrinfection). We demonstrate that, presumably owing to the high molecular weight of factor VIII or its metabolic instability, secretion into the blood and attainment of therapeutic in vivo levels of factor VIII is achieved only if transfected autologous primary fibroblasts or myoblasts are delivered to the liver or spleen, but not if myoblasts are implanted into muscle, a strategy known to be successful for factor IX delivery. | lld:pubmed |
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| pubmed-article:8197198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8197198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8197198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8197198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8197198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8197198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8197198 | pubmed:month | May | lld:pubmed |
| pubmed-article:8197198 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:SchmidtWW | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:BergerMM | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:BirnstielM... | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:WagnerEE | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:CotterAA | lld:pubmed |
| pubmed-article:8197198 | pubmed:author | pubmed-author:ZatloukalKK | lld:pubmed |
| pubmed-article:8197198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8197198 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:8197198 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8197198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8197198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8197198 | pubmed:pagination | 5148-52 | lld:pubmed |
| pubmed-article:8197198 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8197198 | pubmed:meshHeading | pubmed-meshheading:8197198-... | lld:pubmed |
| pubmed-article:8197198 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8197198 | pubmed:articleTitle | In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. | lld:pubmed |
| pubmed-article:8197198 | pubmed:affiliation | Research Institute of Molecular Pathology, I.M.P. Vienna, Austria. | lld:pubmed |
| pubmed-article:8197198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8197198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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