| pubmed-article:8195713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0031526 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0018296 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C1419277 | lld:lifeskim |
| pubmed-article:8195713 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8195713 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8195713 | pubmed:dateCreated | 1994-6-27 | lld:pubmed |
| pubmed-article:8195713 | pubmed:abstractText | The p210bcr/abl tyrosine kinase appears to be responsible for initiating and maintaining the leukemic phenotype in chronic myelogenous leukemia (CML) patients. p21ras-p120GAP interactions play a central role in transducing mitogenic signals. Therefore, we investigated whether p21ras and p120GAP are regulated by p210bcr/abl, and whether this activation is functionally significant for CML cell proliferation. We report that transient expression of p210bcr/abl in fibroblast-like cells induces simultaneous activation of p21ras and inhibition of GTPase-promoting activity of p120GAP, and confirm these data showing that downregulation of p210bcr/abl expression in CML cells with bcr/abl antisense oligodeoxynucleotides induces both inhibition of p21ras activation and stimulation of GTPase-promoting activity of p120GAP. Tyrosine phosphorylation of two p120GAP-associated proteins, p190 and p62, which may affect p120GAP activity, also depends on p210bcr/abl tyrosine kinase expression. Direct dependence of these effects on the kinase activity is proven in experiments in which expression of c-MYB protein in fibroblast-like cells or downregulation of c-MYB expression resulting in analogous inhibition of CML cell proliferation does not result in the same changes. Use of specific antisense oligodeoxynucleotides to downregulate p21ras expression revealed a requirement for functional p21ras in the proliferation of Philadelphia chromosome-positive CML primary cells. Thus, the p210bcr/abl-dependent regulation of p120GAP activity is responsible, in part, for the maintenance of p21ras in the active GTP-bound form, a crucial requirement for CML cell proliferation. | lld:pubmed |
| pubmed-article:8195713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8195713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8195713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8195713 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8195713 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:ZonGG | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:CalabrettaBB | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:PerussiaBB | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:CanaaniEE | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:KanakarajPP | lld:pubmed |
| pubmed-article:8195713 | pubmed:author | pubmed-author:SkorskiTT | lld:pubmed |
