| pubmed-article:8180394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0013878 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0034793 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:8180394 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8180394 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8180394 | pubmed:dateCreated | 1994-6-14 | lld:pubmed |
| pubmed-article:8180394 | pubmed:abstractText | Eosinophil functions can be modulated by several cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5. We have investigated the modulatory role of these cytokines on the interaction of human eosinophils with opsonized particles (serum-treated zymosan [STZ]). Addition of STZ to eosinophils isolated from the peripheral blood of normal human donors resulted in an interaction of the STZ particles with only 15% to 25% of the cells. Treatment of the eosinophils with GM-CSF, IL-3, or IL-5 strongly enhanced both the rate of particle binding and the percentage of eosinophils binding STZ. The effect of the cytokines is most likely mediated by a change in affinity of the complement receptor type 3 (CR3) on the eosinophils for the complement fragment iC3b on the STZ particles. This is indicated by the observation that (1) the effect of the cytokines on STZ binding was prevented by a monoclonal antibody against the iC3b-binding site on CR3 and (2) the enhanced binding was already apparent before upregulation of CR3 on the cell surface was observed. In a previous study, similar results were obtained with platelet-activating factor (PAF)-primed eosinophils. Because we found that the cytokines strongly enhanced the STZ-induced PAF synthesis, we investigated the role of both released PAF and cell-associated PAF in the priming phenomenon by the cytokines. Cytokine priming appeared to be largely independent of the synthesis of PAF. | lld:pubmed |
| pubmed-article:8180394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8180394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8180394 | pubmed:month | May | lld:pubmed |
| pubmed-article:8180394 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:RootGG | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:BlokCC | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:VerhoevenA... | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:KoendermanLL | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:ToolA TAT | lld:pubmed |
| pubmed-article:8180394 | pubmed:author | pubmed-author:KokP TPT | lld:pubmed |
| pubmed-article:8180394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8180394 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8180394 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:8180394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8180394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8180394 | pubmed:pagination | 2978-84 | lld:pubmed |
| pubmed-article:8180394 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:meshHeading | pubmed-meshheading:8180394-... | lld:pubmed |
| pubmed-article:8180394 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8180394 | pubmed:articleTitle | Granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3. | lld:pubmed |
| pubmed-article:8180394 | pubmed:affiliation | Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:8180394 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8180394 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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