| pubmed-article:8178944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8178944 | lifeskim:mentions | umls-concept:C0017658 | lld:lifeskim |
| pubmed-article:8178944 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8178944 | lifeskim:mentions | umls-concept:C0025926 | lld:lifeskim |
| pubmed-article:8178944 | lifeskim:mentions | umls-concept:C1513867 | lld:lifeskim |
| pubmed-article:8178944 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:8178944 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8178944 | pubmed:dateCreated | 1994-6-6 | lld:pubmed |
| pubmed-article:8178944 | pubmed:abstractText | The ability of interleukin-6 (IL-6) to modulate immune parameters and mesangial cell function suggests a role for this cytokine in the development of autoimmune glomerulonephritis. This hypothesis was tested in 6-month-old female (NZB x NZW)F1 mice that were administered recombinant human IL-6 (rhIL-6) (50 and 250 micrograms/kg s.c.) for 12 weeks, resulting in an accelerated and severe form of membranoproliferative glomerulonephritis associated with marked upregulation of mesangial major histocompatibility complex class II antigen and glomerular ICAM-1 expression. To distinguish direct effects of rhIL-6 on the renal mesangium from those mediated through the immune system, (NZB x NZW)F1 mice were immunosuppressed with cyclosporin. Immunosuppression by cyclosporin inhibited the development of glomerulonephritis, decreased class II antigen expression, and abrogated IL-6-mediated effects. Administration of neutralizing anti-IL-6 antibody had no effect on the spontaneous development of glomerulonephritis in (NZB x NZW)F1 mice. This finding, together with undetectable IL-6 serum levels, makes a pathogenetic role of endogenously produced IL-6 in this disease model unlikely. In contrast to (NZB x NZW)F1 mice, parental NZW or BALB/c mice given high doses of rhIL-6 (500 micrograms/kg) or recombinant murine IL-6 (100 micrograms/kg) daily for 4 weeks failed to develop morphological or biochemical evidence of glomerulonephritis. Induction of acute phase proteins, anemia, thrombocytosis, and induction of renal class II antigen confirmed the biological activity of IL-6 in these mice. In conclusion, while non-nephritogenic in normal mice, IL-6 accelerates the development of the genetically determined glomerulonephritis of (NZB x NZW)F1 mice through effects mediated by a modulated immune system. Since neutralizing IL-6 antibody treatment did not prevent the development of glomerulonephritis, it is unlikely that increased IL-6 production plays a role in the pathogenesis of lupus nephritis. | lld:pubmed |
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| pubmed-article:8178944 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8178944 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8178944 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8178944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8178944 | pubmed:month | May | lld:pubmed |
| pubmed-article:8178944 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:MihatschM JMJ | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:GunnHH | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:RomanDD | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:HiestandPP | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:RyffelBB | lld:pubmed |
| pubmed-article:8178944 | pubmed:author | pubmed-author:CarB DBD | lld:pubmed |
| pubmed-article:8178944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8178944 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:8178944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8178944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8178944 | pubmed:pagination | 927-37 | lld:pubmed |
| pubmed-article:8178944 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8178944 | pubmed:meshHeading | pubmed-meshheading:8178944-... | lld:pubmed |
| pubmed-article:8178944 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8178944 | pubmed:articleTitle | Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW)F1 mice. | lld:pubmed |
