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pubmed-article:8174414pubmed:abstractTextIn animals, ileal sensors of nutrients signal satiety more potently than similar sensors in jejunum. We postulated that inadequate food intake and weight loss in human pancreatic insufficiency might arise by the displacement of digestion to ileum, where excessive release of digestive products would enhance satiety. To test this idea, we studied dogs prepared with pancreatic fistulas, which allowed reversible switching of pancreatic juice from entry at duodenum to entry at mid-small intestine. Dogs were studied in a crossover design over successive eight-day periods. Food consumption and body weight were measured while the dogs had continuous access to food. Diversion of pancreatic juice to mid-intestine significantly (P < 0.01) depressed food intake by an average of 28%. Diversion also significantly (P < 0.01) reduced body weight. The findings support the idea that insufficient food intake in human pancreatic insufficiency may result from stimulation of ileal satiety mechanisms.lld:pubmed
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pubmed-article:8174414pubmed:monthMaylld:pubmed
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pubmed-article:8174414pubmed:authorpubmed-author:MeyerJ HJHlld:pubmed
pubmed-article:8174414pubmed:authorpubmed-author:ElashoffJ DJDlld:pubmed
pubmed-article:8174414pubmed:authorpubmed-author:DotyJ EJElld:pubmed
pubmed-article:8174414pubmed:authorpubmed-author:HeY ZYZlld:pubmed
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pubmed-article:8174414pubmed:volume39lld:pubmed
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pubmed-article:8174414pubmed:pagination1014-24lld:pubmed
pubmed-article:8174414pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8174414pubmed:year1994lld:pubmed
pubmed-article:8174414pubmed:articleTitleDisproportionate ileal digestion on canine food consumption. A possible model for satiety in pancreatic insufficiency.lld:pubmed
pubmed-article:8174414pubmed:affiliationDepartment of Medicine, Sepulveda VA Medical Center, California 91343.lld:pubmed
pubmed-article:8174414pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8174414pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:8174414pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed