| pubmed-article:816806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:816806 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:816806 | lifeskim:mentions | umls-concept:C0312452 | lld:lifeskim |
| pubmed-article:816806 | lifeskim:mentions | umls-concept:C0117002 | lld:lifeskim |
| pubmed-article:816806 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:816806 | lifeskim:mentions | umls-concept:C1839141 | lld:lifeskim |
| pubmed-article:816806 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:816806 | pubmed:dateCreated | 1976-7-6 | lld:pubmed |
| pubmed-article:816806 | pubmed:abstractText | An unusual finding of elevated free thyroxine (FT4) concentration coexistent with familial low thyroxine-binding globulin (TBG) is described in a euthyroid patient. Clinical and other laboratory tests were normal and consistent with a clinical diagnosis of euthyroidism. Low TBG (TBG capacity 3-10 mug/100 ml) was confirmed by various electrophoretic procedures and by TBG immunoassay (0.9 mg/100 ml). Serum T4 concentration was low (2.0-5.5 mug/100 ml). Triiodothyronine (T3) resin uptake was increased (88-93%) and the free thyroxine index was normal. Twenty-four-hour thyroidal 131I uptake was normal and varied between 13-20%. Serum thyroid-stimulating hormone (less than 2 muunits) and T3 concentration (80 ng/100 ml) were also normal. Long-acting thyroid stimulator (LATS) was not present. Free T4 concentration measured by dialysis procedure was markedly elevated (9.2-12.1 ng/100 ml). Pulse T3 and T4 tracer kinetic studies by the single compartmental method revealed accelerated blood disappearance of T4 (t 1/2 = 3.7 days) but normal disappearance of T3 (t 1/2 = 2.1 days). Extrathyroidal hormonal iodine pool (569 mug) was in the range of normals. T4 degradation rate (144 mug/70 kg/day) was moderately elevated over the euthyroid mean values, but was still close to or within the upper normal range. T3 degradation was normal (34 mug/day). Failure to develop hyperthyroidism in the presence of elevated free T4 levels, but with normal T3 concentration and dynamics, may suggest that T3, not T4, plays a major role in regulating metabolic activity; alternatively, euthyroidism in this low-TBG patient despite elevated free T4 concentration may simply be explained on the basis of a daily T4 disposal rate which was not clearly abnormal. | lld:pubmed |
| pubmed-article:816806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:816806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816806 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:816806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:816806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:816806 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:816806 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:816806 | pubmed:author | pubmed-author:PremachandraB... | lld:pubmed |
| pubmed-article:816806 | pubmed:author | pubmed-author:GossainV VVV | lld:pubmed |
| pubmed-article:816806 | pubmed:author | pubmed-author:PerlsteinI... | lld:pubmed |
| pubmed-article:816806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:816806 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:816806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:816806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:816806 | pubmed:pagination | 309-18 | lld:pubmed |
| pubmed-article:816806 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-H... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-T... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-T... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-M... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-K... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-S... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-M... | lld:pubmed |
| pubmed-article:816806 | pubmed:meshHeading | pubmed-meshheading:816806-T... | lld:pubmed |
| pubmed-article:816806 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:816806 | pubmed:articleTitle | Increased free thyroxine in a euthyroid patient with thyroxine-binding globulin deficiency. | lld:pubmed |
| pubmed-article:816806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:816806 | pubmed:publicationType | Case Reports | lld:pubmed |
