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pubmed-article:8165224pubmed:abstractTextLong-term potentiation (LTP) has been proposed as a cellular mechanism for associative learning in vertebrates. Induction of one type of LTP--observed at synapses in the CA1 region of the mammalian hippocampus--is regulated by the voltage of the postsynaptic cell. To date, a similar form of LTP has not been demonstrated for any invertebrate synapse. We now report that high-frequency stimulation can induce LTP of sensorimotor synapses of the marine mollusc Aplysia in cell culture. Moreover, induction of this form of LTP appears to involve a voltage-dependent postsynaptic mechanism because pairing tetanic stimulation of the presynaptic cell with strong hyperpolarization of the postsynaptic cell blocks the induction of LTP.lld:pubmed
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pubmed-article:8165224pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8165224pubmed:year1994lld:pubmed
pubmed-article:8165224pubmed:articleTitleLong-term potentiation of Aplysia sensorimotor synapses in cell culture: regulation by postsynaptic voltage.lld:pubmed
pubmed-article:8165224pubmed:affiliationDepartment of Physiological Science, University of California, Los Angeles 90024-1568.lld:pubmed
pubmed-article:8165224pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8165224pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8165224pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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