| pubmed-article:8161934 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8161934 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8161934 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8161934 | pubmed:dateCreated | 1994-5-20 | lld:pubmed |
| pubmed-article:8161934 | pubmed:abstractText | Cytokines play an important role in the regulation of both normal and malignant B cells. In this paper we give a brief overview of the major cytokines involved in the regulation of B-CLL proliferation. In vitro experiments have indicated that there is an antagonistic interaction between TNF-alpha as a growth-enhancing factor and IL-4, which inhibits the growth of B-CLL. We have extended these findings with recent experiments on the intracellular signals which might be involved in these processes. We show that increased levels of intracellular cAMP dose-dependently inhibit the TNF-alpha-induced proliferation of B-CLL. On the basis of these results, we propose a model for the signals involved in the regulation of B-CLL proliferation. The implications for possible new ways of treatment are discussed. | lld:pubmed |
| pubmed-article:8161934 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8161934 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8161934 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8161934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8161934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8161934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8161934 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8161934 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8161934 | pubmed:issn | 1042-8194 | lld:pubmed |
| pubmed-article:8161934 | pubmed:author | pubmed-author:AardenLL | lld:pubmed |
| pubmed-article:8161934 | pubmed:author | pubmed-author:RensinkII | lld:pubmed |
| pubmed-article:8161934 | pubmed:author | pubmed-author:van KootenCC | lld:pubmed |
| pubmed-article:8161934 | pubmed:author | pubmed-author:van OersRR | lld:pubmed |
| pubmed-article:8161934 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8161934 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8161934 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8161934 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8161934 | pubmed:pagination | 27-33 | lld:pubmed |
| pubmed-article:8161934 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:meshHeading | pubmed-meshheading:8161934-... | lld:pubmed |
| pubmed-article:8161934 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8161934 | pubmed:articleTitle | Cytokines and intracellular signals involved in the regulation of B-CLL proliferation. | lld:pubmed |
| pubmed-article:8161934 | pubmed:affiliation | Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:8161934 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8161934 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:8161934 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8161934 | lld:pubmed |
