| pubmed-article:8146183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8146183 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8146183 | lifeskim:mentions | umls-concept:C1155872 | lld:lifeskim |
| pubmed-article:8146183 | lifeskim:mentions | umls-concept:C1567709 | lld:lifeskim |
| pubmed-article:8146183 | lifeskim:mentions | umls-concept:C2698932 | lld:lifeskim |
| pubmed-article:8146183 | lifeskim:mentions | umls-concept:C1328650 | lld:lifeskim |
| pubmed-article:8146183 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8146183 | pubmed:dateCreated | 1994-5-5 | lld:pubmed |
| pubmed-article:8146183 | pubmed:abstractText | The antigen receptors of B and T lymphocytes are encoded in multiple germ-line DNA segments that are joined during lymphocyte development. The recombination-activating proteins RAG-1 and RAG-2 are both essential for this process, termed V(D)J rearrangement. Phosphorylation of the RAG-2 protein at Thr-490 by one or more cyclin-dependent kinases is associated with its rapid degradation. In an immature B-cell line and in normal thymocytes, RAG-2 protein accumulates preferentially in the G0/G1 phases of the cell cycle and declines by at least 20-fold before cells enter S phase. The amount of RAG-2 protein remains low throughout the S, G2, and M phases. The amount of RAG-1 protein shows considerably less fluctuation. The variation in RAG-2 protein is likely to be established, at least in part, by a posttranscriptional mechanism. These observations suggest that V(D)J rearrangement occurs entirely or preferentially within G0/G1. | lld:pubmed |
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| pubmed-article:8146183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8146183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8146183 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8146183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8146183 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8146183 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8146183 | pubmed:author | pubmed-author:DesiderioSS | lld:pubmed |
| pubmed-article:8146183 | pubmed:author | pubmed-author:TURM MMM | lld:pubmed |
| pubmed-article:8146183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8146183 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:8146183 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8146183 | pubmed:geneSymbol | RAG-2 | lld:pubmed |
| pubmed-article:8146183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8146183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8146183 | pubmed:pagination | 2733-7 | lld:pubmed |
| pubmed-article:8146183 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8146183 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8146183 | pubmed:articleTitle | Cell cycle regulation of V(D)J recombination-activating protein RAG-2. | lld:pubmed |
| pubmed-article:8146183 | pubmed:affiliation | Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205. | lld:pubmed |
| pubmed-article:8146183 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8146183 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8146183 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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