| pubmed-article:8141337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0149576 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0226532 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8141337 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:8141337 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:8141337 | pubmed:dateCreated | 1994-4-26 | lld:pubmed |
| pubmed-article:8141337 | pubmed:abstractText | We examined the effect of small changes in extracellular Na+ concentration ([Na+]e) on myogenic tone (MT) in isometrically mounted ring segments of the rabbit facial vein and in pressurized cannulated posterior cerebral artery segments. Decreasing [Na+]e from 150 to 120 mM in the vein increased MT by 24%, and raising [Na+]e to 165 mM attenuated it by 30%. In pressurized posterior cerebral arteries, decreasing [Na+]e to 120 mM reduced the intraluminal diameter by 12%, whereas increasing [Na+]e to 165 mM increased it by 17%. MT was inhibited by amiloride [50% inhibitory concentration (IC50) = 17 +/- 6 microM], an inhibitor of Na(+)-H+ exchange. Diisothiocyanatostilbene sulfonic acid, a Na(+)-Cl(-)-HCO3- cotransporter blocker, inhibited MT with an IC50 of 4.4 +/- 0.65 microM. Ouabain increased MT [50% effective concentration (EC50) = 0.10 +/- 0.04 microM] as did the reintroduction of HCO3- (EC50 5.0 +/- 1.5 mM). Our study suggests that MT in the rabbit posterior cerebral artery and rabbit facial vein is modulated by changes in [Na+]e. This effect is independent of the method used to register changes in wall force. The sensitivity of the tone to changes in [Na+]e and the independence of vessel diameter at different pressures at various [Na+]e may reflect changes in the sensitivity of smooth muscle stretch or mechanoreceptors to [Na+]e. | lld:pubmed |
| pubmed-article:8141337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8141337 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8141337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8141337 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8141337 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8141337 | pubmed:author | pubmed-author:BevanJ AJA | lld:pubmed |
| pubmed-article:8141337 | pubmed:author | pubmed-author:KlaasenAA | lld:pubmed |
| pubmed-article:8141337 | pubmed:author | pubmed-author:LaherII | lld:pubmed |
| pubmed-article:8141337 | pubmed:author | pubmed-author:HenrionDD | lld:pubmed |
| pubmed-article:8141337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8141337 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8141337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8141337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8141337 | pubmed:pagination | H377-83 | lld:pubmed |
| pubmed-article:8141337 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8141337 | pubmed:meshHeading | pubmed-meshheading:8141337-... | lld:pubmed |
| pubmed-article:8141337 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8141337 | pubmed:articleTitle | Myogenic tone of rabbit facial vein and posterior cerebral artery is influenced by changes in extracellular sodium. | lld:pubmed |
| pubmed-article:8141337 | pubmed:affiliation | Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405-0068. | lld:pubmed |
| pubmed-article:8141337 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8141337 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8141337 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
