| pubmed-article:8139659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8139659 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8139659 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:8139659 | lifeskim:mentions | umls-concept:C0043297 | lld:lifeskim |
| pubmed-article:8139659 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:8139659 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:8139659 | pubmed:issue | 6467 | lld:pubmed |
| pubmed-article:8139659 | pubmed:dateCreated | 1994-4-28 | lld:pubmed |
| pubmed-article:8139659 | pubmed:abstractText | X-chromosome inactivation occurs early in mammalian female development to achieve dosage compensation with males. Although it is widely accepted that this inactivation requires the presence in cis of the X-inactivation centre (XIC), it is not known whether the XIC is required for the initiation, promulgation or maintenance of X inactivation. The XIST gene, which is localized within the XIC interval on both the human and mouse X chromosomes, is constitutively expressed from inactive X chromosomes, suggesting a possible role in the maintenance of X inactivation. To address whether the presence of the XIC, including the XIST gene, is continuously required for the maintenance of X-chromosome inactivation, we have analysed the transcriptional activity of a number of X-linked genes in mouse/human somatic cell hybrids retaining an intact human inactive X chromosome or derivatives of the inactive X chromosome lacking the XIC. Genes subject to X inactivation remain transcriptionally silent despite the loss of the XIC, demonstrating that the presence of the XIC is not required for the maintenance of X inactivation in somatic cells. | lld:pubmed |
| pubmed-article:8139659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8139659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139659 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8139659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8139659 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8139659 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8139659 | pubmed:author | pubmed-author:WillardH FHF | lld:pubmed |
| pubmed-article:8139659 | pubmed:author | pubmed-author:BrownC JCJ | lld:pubmed |
| pubmed-article:8139659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8139659 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8139659 | pubmed:volume | 368 | lld:pubmed |
| pubmed-article:8139659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8139659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8139659 | pubmed:pagination | 154-6 | lld:pubmed |
| pubmed-article:8139659 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8139659 | pubmed:meshHeading | pubmed-meshheading:8139659-... | lld:pubmed |
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| pubmed-article:8139659 | pubmed:meshHeading | pubmed-meshheading:8139659-... | lld:pubmed |
| pubmed-article:8139659 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8139659 | pubmed:articleTitle | The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. | lld:pubmed |
| pubmed-article:8139659 | pubmed:affiliation | Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106. | lld:pubmed |
| pubmed-article:8139659 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8139659 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:213742 | entrezgene:pubmed | pubmed-article:8139659 | lld:entrezgene |
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