| pubmed-article:8138266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0333678 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:8138266 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8138266 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8138266 | pubmed:dateCreated | 1994-4-26 | lld:pubmed |
| pubmed-article:8138266 | pubmed:abstractText | Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse-strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity had 20% and 33% survival of more than 100 days, but the other 11 combinations, including four that were fully allogeneic and all with only class I, class II or minor disparities, yielded 45% to 100% survival of more than 100 days. Long-living recipients permanently accepted donor-strain heterotopic hearts transplanted on the same day or donor-strain skin 3 mo after liver transplantation, in spite of detectable antidonor in vitro activity with mixed lymphocyte reaction and cell-mediated lymphocytotoxicity testing (split tolerance). In further donor-specific experiments, liver grafts were not rejected by presensitized major histocompatibility complex class I-disparate recipients and they protected donor-strain skin grafts from second set (or any) rejection. Less frequently, liver transplantation rescued rejecting skin grafts placed 1 wk earlier in major histocompatibility complex class I, class II and minor histocompatibility complex, class II or minor histocompatibility complex-disparate strain combinations. Donor-derived leukocyte migration to the central lymphoid organs occurred within 1 to 2 hr after liver transplantation in all animals examined, persisted in the surviving animals until they were killed (> 375 days), and was demonstrated with double-immunolabeling to be multilineage. The relation of these findings to so-called hepatic tolerogenicity and to tolerance in general is discussed. | lld:pubmed |
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| pubmed-article:8138266 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8138266 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8138266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8138266 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8138266 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:StarzlT ETE | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:RaoA SAS | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:MuraseNN | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:DemetrisA JAJ | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:FungJ JJJ | lld:pubmed |
| pubmed-article:8138266 | pubmed:author | pubmed-author:QianSS | lld:pubmed |
| pubmed-article:8138266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8138266 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:8138266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8138266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8138266 | pubmed:pagination | 916-24 | lld:pubmed |
| pubmed-article:8138266 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:8138266 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8138266 | pubmed:articleTitle | Murine liver allograft transplantation: tolerance and donor cell chimerism. | lld:pubmed |
| pubmed-article:8138266 | pubmed:affiliation | Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213. | lld:pubmed |
| pubmed-article:8138266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8138266 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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