| pubmed-article:8137814 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C0042219 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C1947906 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8137814 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8137814 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8137814 | pubmed:dateCreated | 1994-4-22 | lld:pubmed |
| pubmed-article:8137814 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8137814 | pubmed:abstractText | Many of the vacuolar protein sorting (vps) mutants of Saccharomyces cerevisiae exhibit severe defects in the sorting of vacuolar proteins but still retain near-normal vacuole morphology. The gene affected in one such mutant, vps21, has been cloned and found to encode a member of the ras-like GTP binding protein family. Sequence comparisons with other known GTP binding proteins indicate that Vps21p is unique but shares striking similarity with mammalian rab5 proteins (> 50% identity and > 70% similarity). Regions with highest similarity are clustered within the putative GTP binding motifs and the proposed effector domains of the Vps21/rab5 proteins. Point mutations constructed within these conserved regions inactivate Vps21p function; the mutant cells missort and secrete the soluble vacuolar hydrolase carboxypeptidase Y (CPY). Cells carrying a complete deletion of the VPS21 coding sequence (i) are viable but exhibit a growth defect at 38 degrees C, (ii) missort multiple vacuolar proteins, (iii) accumulate 40-50 nm vesicles and (iv) contain a large vacuole. VPS21 encodes a 22 kDa protein that binds GTP and fractionates with subcellular membranes. Mutant analysis indicates that the association with a membrane(s) is dependent on geranylgeranylation of the C-terminal cysteine residue(s) of Vps21p. We propose that Vps21p functions in the targeting and/or fusion of transport vesicles that mediate the delivery of proteins to the vacuole. | lld:pubmed |
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| pubmed-article:8137814 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8137814 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8137814 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8137814 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8137814 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8137814 | pubmed:month | Mar | lld:pubmed |
