| pubmed-article:8133675 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0225897 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0027100 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:8133675 | lifeskim:mentions | umls-concept:C0439810 | lld:lifeskim |
| pubmed-article:8133675 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8133675 | pubmed:dateCreated | 1994-4-21 | lld:pubmed |
| pubmed-article:8133675 | pubmed:abstractText | The expression of genes coding for the beta 1-adrenergic receptor (beta 1-AR), the alpha subunit of Gs and total myosin heavy chain (MHC) was compared between left ventricles (LV's) from young (6-7 weeks old) and old (22 months old) rats. The mRNA levels were quantitated by Northern or Slot blots analyses using specific DNA probes. Ageing was found to be associated with a reduction in beta 1-AR (77%), G alpha s (33%) and, total MHC (51%) mRNA levels with no concomitant change in 18S RNA and poly(A+) mRNA levels. These results indicate that transcriptional and/or post-transcriptional mechanisms participate in the control of beta-adrenergic receptor density during ageing. As in the senescent LV, beta 1-AR mRNA level is reduced in the hypertrophied LV, whereas the level of G alpha s mRNA is reduced in the senescent but not in the hypertrophied LV. From our data we conclude (1) that a dual mechanism may operate during ageing, mechanical factors indirectly regulating beta 1-AR mRNA level, while changes in G alpha s mRNA level do not depend on hemodynamic load and (2) that the re-expression of beta-MHC mRNA does not compensate for the decreased accumulation of alpha-MHC mRNA which results in a large decrease in the level of total MHC mRNA in the senescent LV. | lld:pubmed |
| pubmed-article:8133675 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8133675 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8133675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133675 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8133675 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8133675 | pubmed:issn | 0047-6374 | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:SwynghedauwBB | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:BourgeoisFF | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:MoalicJ MJM | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:BesseSS | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:MachidaC ACA | lld:pubmed |
| pubmed-article:8133675 | pubmed:author | pubmed-author:HardouinSS | lld:pubmed |
| pubmed-article:8133675 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8133675 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8133675 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:8133675 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8133675 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8133675 | pubmed:pagination | 169-88 | lld:pubmed |
| pubmed-article:8133675 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:meshHeading | pubmed-meshheading:8133675-... | lld:pubmed |
| pubmed-article:8133675 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8133675 | pubmed:articleTitle | Decreased accumulation of beta 1-adrenergic receptor, G alpha s and total myosin heavy chain messenger RNAs in the left ventricle of senescent rat heart. | lld:pubmed |
| pubmed-article:8133675 | pubmed:affiliation | INSERM U 127 Hôpital Lariboisière, Paris, France. | lld:pubmed |
| pubmed-article:8133675 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8133675 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
